Sjögren’s Syndrome and the Salivary Glands Novel Techniques in Diagnosis, Management and Treatment

This book answers questions about the critical role of ultrasound in the management of patients with Sjögren’s syndrome. It also covers developments rheumatologists can foresee in performing a biopsy of the parotid gland.

Each chapter is authored by experts on this condition, emphasizing the extent of current understanding and dealing with unanswered challenges and pitfalls. Topics such as modern imaging techniques like ultrasound and MRI and their importance are given particular focus in this book; practitioners are increasingly using imaging techniques to refine diagnosis and guide clinical management. Additionally, as a significant emerging point of interest in the field, biopsy of the major salivary glands, particularly ultrasound-guided procedures, receives extra attention within the text. The book also includes a chapter that deals with future directions and will also review the challenges patients face with unmanaged Sjögren’s syndrome.

Comprehensive and concise, Sjögren’s Syndrome and the Salivary Glands provides a balanced overview between the chapters and ensure homogeneity of the terminology.

Introduction.- Epidemiology of Sjögren’s syndrome.- The variable clinical presentation of Sjögren’s syndrome.- Diagnostic and classification criteria of Sjögren’s syndrome.- On the complex pathogenesis of Sjögren’s syndrome: epigenetics and epithelial cells.- On the complex pathogenesis of Sjögren’s syndrome: environmental factors and cells of the innate and adaptive immune system.- Juvenile Sjögren’s syndrome.- Anatomy and histology of the salivary glands.- Sonoanatomy of the major salivary glands.- Imaging of Sjögren’s syndrome, with special reference to ultrasound.- Towards a scientific validation of ultrasound for Sjögren’s syndrome.- Ultrasonographic scoring systems – a systematic review.- Biopsy of the minor salivary glands in Sjögren’s syndrome.- Biopsy of the major salivary glands in Sjögren’s syndrome,  with special reference to B cell proliferation.

George A. W. Bruyn, MD, PhD
Consultant Rheumatologist and Department Director
Rheumatology Clinics, Lelystad

After attending medical school in Brussels, Dr. Bruyn did his residency at University Hospital Leiden and rheumatology fellowship at University Hospital Utrecht. He was a consultant rheumatologist at the Medisch Centrum Leeuwarden in the Netherlands as well as at the Antoniusziekenhuis from 1989 to 2009. From 2009 to 2019, he was a rheumatologist and the chair of the rheumatology department at MC Groep Hospitals in Lelystad, the Netherlands. In 2019, he took on the role of director of the Rheumatology Clinics Lelystad . Between 2014 and 2020, he acted as  the co-chair  of the OMERACT Working Group on Ultrasonography and mentored the subgroup on Sjögren’s syndrome. In 1991, he co-founded the Dutch Working Group on Ultrasonography and is a founding member of the Musculoskeletal Ultrasonography Study Group of the American College of Rheumatologyin 1999. In addition, Dr Bruyn serves as a medical expert at the Dutch Court of Appeal in labour law issues.