This book constitutes the refereed proceedings of the 13th International Conference on Verification, Model Checking, and Abstract Interpretation, VMCAI 2012, held in Philadelphia, PA, USA, in January 2012, co-located with the Symposium on Principles of Programming Languages, POPL 2012. The 26 revised full papers presented were carefully reviewed and selected from 70 submissions. The papers cover a wide range of topics including program verification, model checking, abstract interpretation, static analysis, deductive methods, program certification, debugging techniques, abstract domains, type systems, and optimization.