Vascular Dementia Cerebrovascular Mechanisms and Clinical Management

A multidisciplinary survey of our current understanding of the biological and clinical aspects of vascular disease. The authors describe its basic mechanisms, its clinical characteristics, its pharmacological management, and the use of neuroimaging methods to investigate it. The complex relationship between VaD and AD is also fully explored with chapters on how these processes interact and how one disease may lower the threshold for clinical expression of the other.

The Aging Population and the Relevance of Vascular Dementia.- Clinical Forms of Vascular Dementia.- The Neuropathologic Substrates of Vascular-Ischemic Dementia.- Diagnosis of Vascular Dementia.- Basic Mechanisms of Vascular Dementia.- Cerebral Hemodynamics in the Elderly.- The CADASIL Syndrome and Other Genetic Causes of Stroke and Vascular Dementia.- Estrogen, the Cerebrovascular System, and Dementia.- Effects of Hypertension in Young Adult and Middle-Aged Rhesus Monkeys.- The Impact of Vascular Dementia on Cognitive, Psychiatric, and Daily Living.- The Cognitive Profile of Vascular Dementia.- Progression of Cognitive Impairments Associated With Cerebrovascular Disease.- Neuropsychiatric Correlates of Vascular Injury.- Functional Impairment in Vascular Dementia.- Neuroimaging of Vascular Dementia.- Functional Brain Imaging of Cerebrovascular Disease.- Contributions of Subcortical Lacunar Infarcts to Cognitive Impairment in Older Persons.- White Matter Hyperintensities and Cognition.- Poststroke Dementia.- Interactions Between Vascular Dementia and Alzheimer’s Disease.- Understanding Incidence and Prevalence Rates in Mixed Dementia.- Vascular Basement Membrane Abnormalities and Alzheimer’s Disease.- Amyloid Beta and the Cerebral Vasculature.- Cerebrovascular Disease and the Expression of Alzheimer’s Disease.- The Neuropsychological Differentiation Between Alzheimer’s Disease and Subcortical Vsascular Dementia.- Clinical Management of Vascular Dementia.- Pharmacological Treatment of Vascular Dementia.- Understanding and Managing Caregiver Burden in Cerebrovascular Disease.- Quality of Life in Patients With Vascular Dementia.- Approaches to Neuroprotection and Recovery Enhancement After Acute Stroke.