This book constitutes the refereed proceedings of the 10th International Conference on Unconventional Computation, UC 2011, held in Turku, Finland, in June 2011. The 17 revised full papers presented together with 6 extended abstracts of invited talks, and 3 extended abstracts of tutorials were carefully reviewed and selected from 33 initial submissions. The papers are devoted to all aspects of unconventional computation theory as well as experiments and applications. Typical topics are: natural computing including quantum, cellular, molecular, membrane, neural, and evolutionary computing, as well as chaos and dynamical system-based computing, and various proposals for computational mechanisms that go beyond the Turing model.