This volume, the 36th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains eight revised, extended papers selected from the 3rd International Conference on Future Data and Security Engineering, FDSE 2016, and the 10th International Conference on Advanced Computing and Applications, ACOMP 2016, which were held in Can Tho City, Vietnam, in November 2016. Topics covered include big data analytics, massive dataset mining, security and privacy, cryptography, access control, deep learning, crowd sourcing, database watermarking, and query processing and optimization.