Toxicology of the Nose and Upper Airways

The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. Toxicology of the Nose and Upper Airways presents a culmination of knowledge gained as a result of both human and experimental animal studies over the past decade. With contributions from internationally recognized leaders in the fields of experimental toxicology, respiratory medicine, otolaryngology, allergy, and sensory science, this volume:Examines the effect of selected pollutants on the upper airways of both humans and experimental animals—emphasizing mechanistic issues in the processDiscusses epidemiologic findings from populations exposed occupationally or environmentally, comparing and contrasting alternative risk assessment approaches Features clear chapter organization with sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment, and special topicsThis volume is an essential reference for pharmacologists and toxicologists concerned with the nose and upper airway, as well as clinicians, risk assessors, and sensory scientists.

Structure & function in the upper airway Functional anatomy of the upper airway in experimental animals Functional anatomy of the upper airway in humans Functional neuroanatomy of the upper airway in experimental animals Functional neuroanatomy of the human upper airway Mucosal enzymology of the upper airway. Dosimetry & Toxicokinetics of Nasal Exposure Upper airway dosimetry of gases, vapors and particulate matter in experimental animals Upper airway dosimetry of gases and vapors in humans Upper airway dosimetry of particulate matter in humans. Functional & Pathologic Responses and Their Measurement Exposure and recording systems in human studies Biomarkers of nasal toxicity in experimental animals Biomarkers of nasal toxicity in humans Nasal reflexes - including alterations in respiratory behavior - in experimental animals Nasal chemosensory irritation in humans Nasal reflexes in humans Olfactory toxicity in humans and experimental animals Inflammatory conditions of the nose and paranasal sinuses in experimental animals Inflammatory conditions of the nose and paranasal sinuses in humans Chronic tissue changes and carcinogenesis in the upper airway. Responses to Specific Agents Second hand tobacco smoke exposure in humans Chlorine exposure in humans and experimental animals Hydrogen sulfide exposure in experimental animals Sulfur dioxide exposure in humans Exposure to volatile organic compounds in humans. Risk Assessment and Special Topics Benchmark dose and noncancer risk assessment for the upper airways Physico-chemical modeling of sensory irritation in humans and experimental animals Effect of allergic inflammation on irritant responsiveness in the upper airwa

John B. Morris is Professor and Head of Pharmaceutical Sciences and Assistant Dean for Research at the University of Connecticut. He received his Ph.D. in Toxicology at the University of Rochester in 1979 and carried out a Postdoctoral fellowship in Inhalation Toxicology at New York University. In 1981 he joined the faculty at the University of Connecticut. Dr Morris has authored over 70 peer-review articles and book chapters. He is currently on the editorial board of Inhalation Toxicology.Dennis J. Shusterman is Professor of Clinical Medicine, Emeritus at the University of California, San Francisco (UCSF). He received his M.D. from University of California, Davis in 1978, and M.P.H. from University of California, Berkley in 1982. He currently serves as a Section Chief within the Occupational Health Branch of the California Department of Public Health, and is an attending physician in the Occupational and Environmental Medicine Clinic at UCSF. He is the author of over 70 peer-reviewed publications in the field of inhalation toxicology and occupational and environmental medicine.