Tocotrienols Vitamin E Beyond Tocopherols, Second Edition

The first 90 years of vitamin E research has produced prolific and notable discoveries, but until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Currently, the non-tocopherol vitamin E molecule tocotrienol has reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years has been published since 2009. The thriving field of tocotrienol research gives ground for publication of Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition, a compilation of the latest tocotrienol research in all new chapters. Highlights Established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer Emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extension, and skin health Tocopherol interference with tocotrienol functions All new chapters and many new contributors Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis, and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book overviews tocotrienols, and examines their sources, chemistry, and mechanisms of action. Contributors discuss the role of tocotrienols in the treatment and prevention of cancer and in cardiovascular health, diabetes, and other hormone regulation by tocotrienols. In addition, the book addresses animal and in vitro as well as mechanistic and pre-clinical studies.Dr. Tan discusses the benefits of tocotrienol in a YouTube video.

Tocotrienols in Plants: Occurrence, Biosynthesis, and FunctionMaren Müller, Jana Cela, María A. Asensi-Fabado, and Sergi Munné-BoschSafety of Unsaturated Vitamin E Tocotrienols and Their IsomersAlexander G. Schauss, John R. Endres, and Amy ClewellBioavailability and Metabolism of TocotrienolsZhihong Yang, Mao-Jung Lee, Shengming Sang, and Chung S. YangBioavailability of Tocotrienols and Interference of Their Bioavailability by a-Tocopherol SupplementationSaiko Ikeda, Tomono Uchida, and Chisato AbeAlpha-Tocopherol: A Detriment to Tocotrienol BenefitsAnne M. Trias and Barrie TanAntiangiogenic Effects of TocotrienolTakahiro Eitsuka, Kiyotaka Nakagawa, and Teruo MiyazawaMechanism of Delta-Tocotrienol on Colorectal CancerSayori Wada and Yuji NaitoTargeted Prostate Cancer Chemoprevention Trial with TocotrienolsWilliam L. Stone, Victoria P. Ramsauer, Sharon E. Campbell, and Koymangalath Krishnand-Tocotrienol: Demethylated Vitamin E with Hormetic Function and Therapeutic Application in Breast CancerFrancesca Pilolli, Marta Piroddi, Elisa Pierpaoli, Silvia Ciffolilli, Mauro Provinciali, and Francesco GalliMevalonate-Suppressive Tocotrienols for Cancer Chemoprevention and Adjuvant TherapyHuanbiao Mo, Manal Elfakhani, Anureet Shah, and Hoda YeganehjooPotential of Tocotrienols in Lung CancerXiangming Ji, Arvind Goja, and Smiti V. GuptaTocotrienols and Atherosclerosis: Potential in CardioprotectionHapizah Mohd NawawiTocotrienols: Viable Options for Managing Metabolic DiseasesChi-Wai WongTocotrienols as Possible Treatments for ObesityWong Weng-Yew and Lindsay BrownTocotrienols, Inflammation, and Cancer: How Are They Linked?Sahdeo Prasad, Bokyung Sung, Sridevi Patchva, Subash C. Gupta, and Bharat B. Aggarwal1-Modulating NF-?B Activity by TocotrienolsMary Kaileh and Ranjan SenAntioxidant Action of TocotrienolsEtsuo NikiTocotrienol in Human Pancreatic CancerMokenge P. Malafa and Kazim HusainTocotrienols in the Treatment of DyslipidemiaMark HoustonTocotrienols and Vascular EffectsAida Hanum Ghulam RasoolProlongevity Effects of Tocotrienols: Trials in Caenorhabditis elegansNoriko Kashima, Yukiko Fujikura, Tomomi Komura, Yoshikazu Nishikawa, Keiji Terao, and Barrie TanAnti-Tyrosinase Activity of Tocotrienol in Skin BlemishesDaniel Yee Leng YapTocotrienols and Bone HealthIma Nirwana Soelaiman, Norazlina Mohamed, Ahmad Nazrun Shuid, and Norliza MuhammadTocotrienol and Physiology of ReproductionM.H. Rajikin, N. Mokhtar, A. Chatterjee, and Y.S. KamsaniTocotrienol and Tocopherol in Stress-Induced Gastric Mucosal InjuryNafeeza Mohd Ismail and Ibrahim Abdel Aziz IbrahimStructural Modification of Tocotrienols to Improve BioavailabilityAwantika Singh, Philip J. Breen, Sanchita Ghosh, K. Sree Kumar, Kottayil I. Varughese, Peter A. Crooks, Martin Hauer-Jensen, and Cesar M. CompadreIndex

Barrie Tan is the President of American River Nutrition, Inc. in Hadley, Massachusetts, USA. Ronald Ross Watson is a Professor in the College of Public Health and School of Medicine at the University of Arizona, Tucson, USA. Victor R. Preedy is the Director of the Genomics Centre at King's College London, UK.