Therapeutic Platform of Bioactive Lipids Focus on Cancer

Bioactive lipid metabolism and signaling are now widely accepted as major players in cancer biology. This volume helps to fill the urgent need to explore and investigate the innovations, current shortcomings, and future challenges of cancer therapy through the bioactive lipids by presenting new research on the use of bioactive lipids as effective weapons against cancer. The volume introduces the subject and then goes on to cover the chemistry, formulation, and mechanism of bioactive lipids in cancer. The volume takes a close look at lipoxins, ceramides, resolvins, and sphingosine-1-phosphate and their roles in cancer treatment. It also addresses the formulations based on bioactive lipids for the treatment of cancer. A variety of mechanisms of bioactive lipids as novel therapies are also covered, including using computational techniques to identify bioactive lipid drug targets, targeting therapy via KRAS and PI3K signals, and others. The authors also discuss the role and effects of various substances and their effect on various cancers, including colorectal cancer, prostate cancer, breast cancer, and others. The application of lysophosphatidic acid, lipopolysaccharide, lipid-soluble bioactive substance from avocado, omega-3 polyunsaturated fatty acids-derived lipid metabolites, and more are covered as well. The volume offers academia, technologists, and scientists from different disciplines valuable information to gain knowledge of bioactive lipid metabolism and signaling as an anti-cancer weapon in their fight against cancer.

PART I: CHEMISTRY OF BIOACTIVE LIPIDS 1. Ceramide: A Sphingolipidic Weapon Against Cancer Suvadeep Mal, Udita Malik, Suman Das, and Sudhir Kumar Paidesetty 2. Lipoxins: Emerging Players in the Resolution of Cancer Rati Kailash Prasad Tripathi 3. Role of Resolvins in Treatment of Cancer as a Bioactive Lipid Suman Das, Suvadeep Mal, and Udita Malik 4. Sphingosine-1-Phosphate: An Important Target to Fight Against Cancer Udita Malik, Suvadeep Mal, Suman Das, and Dilip Kumar Pal PART II: FORMULATION BASED ON BIOACTIVE LIPIDS 5. Bioactive Lipids for the Treatment of Cancer Biswajit Basu, Tiyas Pal, Swarupananda Mukherjee, and Bhupendra G. Prajapati 6. Role of Exosomes as Natural Conveyors of Bioactive Lipids in Cancer Sapna Jain and Jonathan Pillai PART III: MECHANISM OF BIOACTIVE LIPIDS 7. Identification of Bioactive Lipid Drug Targets by Computational Techniques Aakriti Garg, Ruchika Sharma, Santanu Kaity and Anoop Kumar 8. Metabolism of Lipids in Malignant Solid Tumors under Hypoxia and Drug Targets Lakhveer Singh, Sakshi Bajaj, Gaurav Kaithwas, and Manjusha Choudhary 9. Novel Targeting Therapy for Colorectal Cancer with Special Emphasis on KRAS and PI3K Pathway Ram Kumar Sahu, Aseem Setia, and Jiyauddin Khan 10. Role of Lipid-Soluble Bioactive Substance from Avocado for Inhibition of Prostate and Other Cancers Dilipkumar Pal and Khushboo Raj 11. Role of Lipopolysaccharide in the Pathogenesis of Cancer Siddhant Mitra and Sugato Banerjee 12. Role of Lysophosphatidic Acid on Cancer Dilipkumar Pal and Supriyo Saha 13. Role of Omega-3 Polyunsaturated Fatty Acids-Derived Lipid Metabolites on Cancer Hacks Souvik Mukherjee, Gaurav Kaithwas, Manjari Singh, and Subhasis Banerjee

Manjari Singh, PhD, is currently working as an Assistant Professor in the Department of Pharmaceutical Sciences, Assam Central University, Silchar, India. She received her PhD degree from Babasaheb Bhimrao Ambedkar University, Lucknow, India. During the doctoral study, she has identified some novel prolyl-hydroxylase activators as potent breast cancer therapeutics. Her research area is focused on the regulation of hypoxia in the tumor microenvironment, in silico-based drug discovery, and in-vitro/in vivo disease models in cancer. Dr. Singh is a member of multiple editor/reviewer boards of different reputed journals and is a recipient of the various research grant. She has published 37 journal papers (authored/co-authored), four book chapters to date, and also been involved in pharmacology teaching to the graduate student.