The Influence of Antibiotics on the Host-Parasite Relationship III

When comparing the number of contributions for the proceedings of the third symposium on The Influence of Antibiotics on the Host-Parasite Relationship with those of its two predecessors, one becomes aware of the progress that has been made in this field. It is obvious that the design of experiments has substantially refined and therefore the clinical relevance of the results has gained in significance. The editors of this volume would like to thank all the colleagues who contributed to this book. It is hoped that interest in this field will develop further and that it will finally yield results which one day may be the basis for an improvement of antibiotic therapy. Bochum WOLFGANG OPFERKUCH Contents Opening Remarks P. G. Quie .... Interactions Between Antibiotics, Phagocytes, and Bacteria W. L. Hand, N. L. King-Thompson, T. H. Steinberg, and D. L. Hand. With 2 Figures and 5 Tables . . . . . . .. 4 Influence of Antibiotics on the Cell Surface of Escherichia coli H. Leying, S. Suerbaum, H.-P. Kroll, J. Gmeiner, and W. Opferkuch. With 2 Figures and 3 Tables . . . . . 17 Pseudomonas aeruginosa: Alterations Induced by Low Concentrations of 4-Quinolones M. T. Labro, A. Bryskier, C. Babin-Chevaye, and J. Hakim.

Opening Remarks.- Interactions Between Antibiotics, Phagocytes, and Bacteria.- Influence of Antibiotics on the Cell Surface of Escherichia coli.- Pseudomonas aeruginosa: Alterations Induced by Low Concentrations of 4-Quinolones.- Interference of Tunicamycin-Induced Staphylococcal Lectin Dysfunction with Specific Adherence Mechanisms and Immune Responses.- An In Vitro Model to Investigate the Influence of Antibiotics on Bacterial Susceptibility to Surface Phagocytosis by Human Polymorphonuclear Leukocytes.- Growth Rate, Iron Depletion, and a Sub-Minimal Inhibitory Concentration of Penicillin G Affect the Surface Hydrophobicity of Staphylococcus aureus.- Reduced Wall Degradation of Staphylococci After Pretreatment with Bacteriostatic Antibiotics.- Influence of Subinhibitory Concentrations of Ceftriaxone on Opsonic Requirements of Pseudomonas aeruginosa.- Traditional Chinese Medicines and Drugs in Relation to the Host-Defense Mechanism.- Influence of Antibiotic Therapy of Mice on the Humoral Immune Response Against Sheep Erythrocytes.- Influence of Ciprofloxacin Treatment In Vivo on Cell-Mediated Immunity to Listeria monocytogenes.- Enzymatic Conversion of [3H]Clindamycin by the Human Neutrophil.- Antibiotic Modulation of Host Defense.- In Vitro and Ex Vivo Effect of Cefodizime on Phagocytosis.- Antibacterial Substance(s) from Hypericum perforatum: Influence on Phagocytosis of Escherichia coli by Human Neutrophils.- Influence of the Tetrachlorodecaoxygen Anion Complex on Phagocytosis of Peripheral Human Polymorphonuclear Cells in Chemiluminescence Assays.- Influence of RO 236240 on Human Polymorphonuclear Leukocytes In Vitro.- Interactions Among Subinhibitory Antibiotics, Aerobic Gram-negative Rods, and Human Polymorphonuclear Neutrophils.- Effects of Glycopeptide and Lipopeptide Antibiotics on Granulocyte Function In Vitro.- Determination of Intracellular Antibacterial Activity of Antibiotics by Means of a Fluorochrome Microassay.- Effect of New Antibacterial Agents on Intracellular Staphylococci and Mycobacteria.- Effects of Beta-Lactam Antibiotics on the Lymphocyte Responses In Vitro and in Animals.- Effect of Trimethoprim/Sulfamethoxazole on Human Neutrophil Function and Survival of Mice Infected with Candida.- Effects of Selected Antibiotics on Experimental Candidiasis in Cyclophosphamide-Treated Mice: An In Vivo Model to Evaluate the Antibiotic Effect on Granulocytopoiesis.- Immunomodulating Effect of Fosfomycin.- Effects of Antibiotics on Resistance to Colonization with Enteric Pathogens in Mice.- Influence of Antibiotics on Biochemical Intestinal Microflora-Associated Characteristics in Man and Animals.- Antibiotics and the Host-Parasite Relationship in Cystic Fibrosis.- Absence of a Postantibiotic Effect in Experimental Left-Sided Streptococcus faecalis Endocarditis Treated with Penicillin Plus Gentamycin.- Absence of a Postantibiotic Effect in Experimental Left-Sided Pseudomonas aeruginosa Endocarditis Treated with Imipenem with or Without Gentamicin.- Influence of Mezlocillin Administration to Pregnant Mice on the Immune System of Their Offspring.- Changes in the Immune Parameters of Antibiotic-Bacterial Interactions Induced by Hypothalamic and Other Electrolytic Brain Lesions Produced Through Stereotaxically Implanted Depth Electrodes.- In Vitro Effect of Different Antimicrobial Agents on Il-2 Production and Il-2 Receptor Expression of Human Lymphocytes.- Effect of 4-Quinolone Antibiotics on Cell Function, Cell Growth, and Pyrimidine Nucleotide Biosynthesis in Human Lymphocytes In Vitro.- Enhancement by Ampicillin or Cyclacillin Pretreatment of E. coli of Phagocytosis, Blastogenesis, and Production of Lymphokines, Interferons, and Tumor Necrosis Factor.- Effect of Beta-Lactam-Antibiotics on Eukaryotic DNA Replication: Possible Impact on the Host-Parasite Relationship.- Interaction Between the DNA-Gyrase Inhibitor Coumermycin and the Membrane of Human Neutrophils.- Concluding Remarks.