Statistics in Toxicology A Volume in Memory of David A. Williams

This collection of papers on aspects of statistics in toxicology is will be of interest to all medical statisticians. Toxicology is indeed an area which presents challenging statistical problems. The authors are internationally known and respected and include A. Whitehead and R. N. Connor (University of Reading) L. Ryan (Harvard) A. P. Grieve (Pfizer Research) This is the latest in the popular Royal Statistical Society Lecture Series, and will be essential reading for all those involved in this area.

1 - Are animal experiments in toxicological research the 'right' size?
2 - Estimating dose-response for toxic end-points
34. - A literature review of statistical methods for the analysis of general toxicology datasStatistical analysis of genetic toxicology test data
5 - Some observations on detecting extra-binomial variability within the beta-binomial model
6 - C(alpha) tests for homogeneity of proportions in toxicology in the presence of beta-binomial overdispersion
7 - Overdispersion in logistic-linear models
8 - On likelihood and Bayesian methods for interval estimation of the LD50
9 - The analysis of grouped longitudinal mortality data allowing for variable natural mortality
10 - Statistical evaluation of the fixed-dose procedure
11 - Statistical analysis of overdispersed multinomial data from development toxicity studies
12 - Trend tests for clustered data
13 - Exploratory and model-based inference in toxicokinetics