Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth Edition

As knowledge of biological systems and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth Edition provides an introduction to the principles of rational drug design, including both novel and established approaches. This new edition adopts a 'from-bench-to-marketplace' approach, using real examples where possible. In addition to a comprehensive update of the previous edition, new advances in molecular techniques, biotechnological applications and computer-aided design have been added.

Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. Using real-world examples that illustrate the principles of drug design, the author explores the discovery of lead compounds and their manipulation in the production of non-toxic, metabolically stable drug candidates that will interact with target receptors in a predicted fashion. See what’s new in the Fourth Edition: Fully updates and expands the contents Coverage of agonists and antagonists of neuro-transmitters Information on the design of stable peptide-like drugs The human genome and its impact on drug discovery and development Advances in therapy and pharmacokinetics Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit.

Contents Processes of Drug Handling by the Body, M. Gumbleton The Design of Drug Delivery Systems, I.W. Kellaway Fundamental Pharmacokinetics, G. Taylor Intermolecular Forces and Molecular Modeling, R.H. Davies Drug Chirality and its Pharmacological Consequences, A.J. Hutt Quantitative Structure–Activity Relationships (QSAR) in Drug Design, J.C. Dearden and M.T.D. Cronin Prodrugs, A.W. Lloyd From Program Sanction to Clinical Trials: A Partial View of the Quest for Arimidex, A Potent, Selective Inhibitor of Aromatase, P.N. Edwards Design of Enzyme Inhibitors as Drugs, A. Patel, H.J. Smith, and T. Steinmetzer Peptide Drug Design, D.J. Barlow Combinatorial Chemistry: A Tool for Drug Discovery, B. Kellam Recombinant DNA Technology: Monoclonal Antibodies, F.J. Rowell The Human Genome and its Impact on Drug Discovery and Therapy, F.J. Rowell The Chemotherapy of Cancer, D.E. Thurston Neurotransmitters, Agonists, and Antagonists, R.D.E. Sewell, H.J. Smith, H. Stark, W. Schunack, and P.G. Strange Design of Antibacterial, Antifungal, and Antiviral Agents, C. Simons and A.D. Russell Pharmaceutical Applications of Bioinorganic Chemistry, D.M. Taylor and D.R. Williams Index