Skin Decontamination A Comprehensive Clinical Research Guide

The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. However, some chemicals act directly on the skin including vesicants sulfur mustard and corrosive compounds such as strong acids or bases, and do not have to gain access to systemic circulation to cause extensive skin damage. Early and rapid skin decontamination is extremely important following exposure to chemical warfare agents and toxic industrial chemicals because it decreases serious skin damage to the patient and, potentially, their doctor. 

This multi-authored international text pulls together a century of decontamination research and helps the reader expedite solutions that will decrease morbidity and mortality. Complete with dozens of hiqh quality photographs and illustrations, Skin Decontamination aids industrial hygiene, dermatology, occupational physicians and those involved in the public health arena. 

Chapter 1. Isolated Human and Animal Stratum Corneum As a Partial Model for the 15 Steps of Percutaneous Absorption: Emphasizing Decontamination, Part I

Xiaoying Hui and Howard I. Maibach

Chapter 2. Isolated Human And Animal Stratum Corneum As A Partial Model For The 15 Steps Of Percutaneous Absorption: Emphasizing Decontamination Part II

Xiaoying Hui and Howard I. Maibach

Chapter 3. Recent Knowledge: Human/Animal Skin Decontamination

Christina Phuong and Howard I. Maibach

Chapter 4. The Decontamination of Chemically Contaminated Remains

Jill A. Harvilchuck, Dan Noort, Glenn Lawson, Kelly Kyburz, Miranda Verschraagen, and Alison Director-Myska

Chapter 5. Effectiveness of Chemical, Biological, Radiological, and Nuclear (CBRN) Skin Decontaminants: Towards Tests Standardization

Colonel Denis Josse

Chapter 6. Effects of Soap-Water Wash on Human Epidermal Penetration

Hanjiang Zhu1, Eui-Chang Jung, Christina Phuong, Xiaoying Hui, and Howard Maibach

Chapter 7. Fuller's Earth: Old and Faithful Skin Decontaminant Against Toxic Agents

Shlomit Dachir, Eliezer Fishbine, Yakov Meshulam, Hillel Buch, Nahum Allon, and Tamar Kadar

Chapter 8. Comparison of Four Different Fuller’s Earth Formulations in Skin Decontamination

Annick Roul, Cong-Anh-Khanh Le, Marie-Paule Gustin, Emmanuel Clavaud, Bernard Verrier, Fabrice Pirot, and Françoise Falson

Chapter 9. The Mass Decontamination Paradigm: Response Relating to Gas Phase Exposures and Skin Decontamination

Christina Baxter, Sharyn Gaskin, Michael Logan, and Dino Pisaniello

Chapter 10. Binding Affinity and Decontamination of Dermal Decontamination Gel (DDGel) to Model Chemical Warfare Agent (CWA) Simulants

Yachao Cao, Akram Elmahdy, Hanjiang Zhu, Xiaoying Hui, and Howard Maibach

Chapter 11. Dermostyx (IB1): High-efficacy and Safe Topical Skin Protectant Against Percutaneous Toxic Agents

Chapter 12. Understanding the Impact of Responder Management Strategies on Public Experiences and Behaviour During Mass Decontamination

Holly Carter, John Drury, and Richard Amlôt

Hanjiang Zhu, PhD

University of California San Francisco, Dermatology

Department of Dermatology

2340 Sutter Street N461

San Francisco, CA 94143/0989        

USA

Tel: 408-829-3797

Fax: 415-753-5304

sunnie.zhu@foxmail.com

Howard I. Maibach, MD                                                                   

Professor, Dermatologist

2340 Sutter Street N461

San Francisco, CA 94143/0989         

USA

Tel: (415) 673-9693   

Fax: (415) 673-3533