Risk Assessment with Time to Event Models

How can environmental regulators use information on 48-hour toxicity tests to predict the impacts of a few minutes of pollution? Or, at the other extreme, what is the relevance of 96-hour toxicity data for organisms that may have been exposed to a pollutant for six months or a couple of years? The key to answering these types of questions lies in the time-course of toxic effect. Risk Assessment with Time to Event Models is the first comprehensive treatment of these time-to event methods in the context of ecological risk assessment. Leading experts from industry, academia, and government regulatory agencies explain how these methods can be used to improve risk assessment.

How can environmental regulators use information on 48-hour toxicity tests to predict the effects of a few minutes of pollution? Or, at the other extreme, what is the relevance of 96-hour toxicity data for organisms that may have been exposed to a pollutant for six months or more? Time to event methods are the key to answering these types of questions. Risk Assessment with Time to Event Models is the first comprehensive treatment of these methods in the context of ecological risk assessment. Leading experts from industry, academia, and government regulatory agencies explain how these methods can be used to extract more useful information from laboratory data than is present in simple summary statistics like 48-h LC50. The book offers a clear introduction to the field through several approaches, from the introductory to the more mathematical. Risk Assessment with Time to Event Models demonstrates the relevance of time in the analysis and reporting of toxicity data through the use of practical examples from the field of environmental toxicology. It also incorporates helpful analogies from other disciplines that commonly use time to event modeling.

Introduction to Time to Event Methods, M.C. Newman and M. CraneTime to Event Analysis of Standard Ecotoxicity Data, M. Crane and A. GrossoApplying Time to Event Methods to Assess Pollutant Effects on Populations, M.C. Newman and J.T. McCloskeyTime-Concentration-Effect Models in Predicting Chronic Toxicity from Acute Toxicity Data, F.L. Mayer, M.R. Ellersieck, G.F. Krause, K. Sun, G. Lee, and D.R. BucklerJust How Much Better is a Time to Event Analysis? P.M. DixonUsing Time to Event Modelling to Assess the Ecological Risk of Produced Water Discharges, C.C. KarmanTime to Event Analysis in the Agricultural Sciences, J.S. FenlonTime to Event Analysis in Ecology, B.F. ManlyTime to Event Methods in Engineering, A. KimberCan Risk Assessment be Improved with Time to Event Models? M. Crane, P.F. Chapman, T. Sparks, J. Fenlon, and M.C. NewmanConclusions, M. Crane, P.F. Chapman, and M.C. Newman

Mark Crane, Michael C. Newman, Peter F. Chapman, John S. Fenlon