Regenerative Engineering

Distinct from tissue engineering, which focuses primarily on the repair of tissues, regenerative engineering focuses on the regeneration of tissues: creating living, functional tissue that has the ability to replace organs that are dysfunctional. The challenge of working in an area like regenerative engineering lies, in part, in the breadth of information required to truly appreciate and begin to think about this field. Regenerative Engineering introduces the field through the presentation of fundamental concepts of cell biology, stem cell science, materials science, and cell-material interactions. It also focuses on specific organ and tissue types and presents up-to-date examples of ongoing work, often in the context of a specific clinical need. Regenerative medicine focuses on the biological aspects of tissue regeneration via stem cells, factors, and cytokines, while tissue engineering focuses on the integration of materials science and life sciences. This book integrates these two areas, presenting each concept in the framework of regenerative engineering. Features: Covers a number of cutting-edge topics related to regenerative medicine and tissue engineering Includes an introductory chapter on materials science Features a number of the contributors who are world-class researchers, one of whom is Dr. Anthony Atala, whose work dealing with organ regenerative engineering was featured on Sixty Minutes Incorporates problem-based learning throughout the text, which is not hypothetical but based on actual biological, engineering, or clinical scenarios Combining science, engineering and medicine, Regenerative Engineering incorporates all of the essential elements needed for further advancement in this field. The book explores the development and examination of vital organs and tissue types and addresses concerns as it relates to the regenerative engineering of various organ tissues, vascular tissues, bone, ligament, neural tissue, and the interfaces between tissues.

Regenerative Engineering: The Future of Medicine Saadiq F. El-Amin III , MD , PhD; Joylene W.L. Thomas, MD ; Ugonna N. Ihekweazu, MD ; Mia D. Woods, MS; and Ashim Gupta, MS Cell Biology Gloria Gronowicz, PhD and Karen Sagomonyants, DMD Stem Cells and Tissue Regeneration Kristen Martins-Taylor, PhD; Xiaofang Wang, MD , PhD; Xue-Jun Li, PhD; and Ren-He Xu, MD , PhD Introduction to Materials Science Sangamesh G. Kumbar, PhD and Cato T. Laurencin, MD , PhD Biomaterials A. Jon Goldberg, PhD and Liisa T. Kuhn, PhD In Vitro Assessment of Cell–Biomaterial Interactions Yong Wang, PhD Host Response to Biomaterials and Its Implications in Regenerative Engineering Lakshmi S. Nair, MPhil, PhD Organ Regenerative Engineering: Cell Sources, Considerations, and Strategies Anthony Atala, MD; Meng Deng, PhD; and Yusuf Khan, PhD Cardiovascular Regenerative Engineering Rebekah A. Neal, PhD; Anusuya Das, PhD; and Edward A. Botchwey, PhD Bone Regenerative Engineering Yusuf Khan, PhD; Anil Magge, BS; and Cato T. Laurencin, MD , PhD Engineering Tissue-to-Tissue Interfaces Nancy M. Lee, ME ng; Nora T. Khanarian, PhD; Jung Hyun Park, PhD; and Helen H. Lu, PhD Neural Regenerative Engineering Shyam Aravamudhan, PhD and Ravi V. Bellamkonda, PhD Ligament Regenerative Engineering Parimala S. Samuel, MS; Benjamin R. Mintz, BS; Kristen L. Lee, BS; and James A. Cooper, Jr., PhD Skeletal Muscle Regenerative Engineering Shaun W. McLaughlin, BS; Michael N. Wosc zyna, PhD; Cato T. Laurencin, MD , PhD; and David J. Goldhamer, PhD Engineering Limb Regeneration: Lessons from Animals That Can Regenerate David M. Gardiner, PhD; Susan V. Bryant, PhD; and Ken Muneoka, PhD Index .

Cato T. Laurencin, MD, PhD, earned his BSE in chemical engineering from Princeton University, his PhD in biochemical engineering/biotechnology from the Massachusetts Institute of Technology, and his MD magna cum laude from Harvard Medical School. Dr. Laurencin is currently the chief executive officer of the Connecticut Institute for Clinical and Translational Science and director of the Institute for Regenerative Engineering at the University of Connecticut. He previously served as the vice president for health affairs and dean of the School of Medicine. He is a university professor and holds the Van Dusen Endowed Chair in the Department of Orthopaedic Surgery. Yusuf Khan, PhD, earned his master’s degree and PhD from Drexel University in biomedical engineering. He is currently an assistant professor at the Institute for Regenerative Engineering and the Department of Orthopaedic Surgery at the University of Connecticut Health Center. He has an appointment in the Department of Chemical, Materials, and Biomolecular Engineering and is part of the Department of Biomedical Engineering within the School of Engineering at the University of Connecticut. His research interests include musculoskeletal tissue regeneration using implantable biodegradable scaffolds, development of composite structures for bone regeneration, and the development of clinically relevant healing modalities using ultrasound.