Polymeric Drugs and Drug Delivery Systems

Polymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume consists of twenty-two recent research-based reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports were prepared by top scientists in the field and are based on current research conducted at leading laboratories in the U.S.A., Europe, and Asia. These 22 chapters report the latest information in the application of polymers to biological systems.

Semitelechelic Poly[N-(2-hydroxypropyl)-methacrylamide] for Biomedical Applications. Thermoresponsive Polymeric Micelles for Double Targeted Drug Delivery. pH/Temperature-Sensitive Polymers for Controlled Drug Delivery. Design of Polymeric Systems for Targeted Administration of Peptide and Protein Drugs. Drug Release from Ionic Drugs from Water-Insoluble Drug-Polyion Complex Tablets. Polychelating Amphiphilic Polymers (PAP) as Key Components of Microparticulate Diagnostic Agents. Bioconjugation of Biodegradable Poly(lactic/glycolic acid) to Protein, Peptide, and Anti-Cancer Drug: An Alternative Pathway for Achieving Controlled Release from Micro- and Nanoparticles. Elastin-Mimetic Protein Networks Derived from Chemically Crosslinked Synthetic Polypeptides. Genetically Engineered Protein Domains as Hydrogel Crosslinks. Superporous Hydrogel Composites: A New Generation of Hydrogels with Fast Swelling Kinetics, High Swelling Ratio and High Mechanical Strength. Structure and Solute Size Exclusion of Poly(methacrylic acid)/ Poly(N-isopropyl acrylamide) Interpenetrating Polymeric Networks. Thermodynamics of Water Sorption in Hyaluronic Acid and Its Derivatives. Photocrosslinked Polyanhydrides with Controlled Hydrolytic Degradation. Novel Cytokine-Inducing Macromolecular Glycolipids from Gram-Positive Bacteria. Hydrophobe Modified Cationic Polysaccharides for Topical Microbicide Delivery. Novel Antimicrobial N-Halamine Polymer Coatings. Design of Macromolecular Prodrug of Cisplatin Attached to Dextran through Coordinate Bond. Synthesis of Linear and Hyperbranched Stereoregular Aminopolysaccharides. Diameter and Diameter Distributions of Poly(L-lactide) Microspheres by Ring-Opening Polymerization of L-Lactide and from Earlier Synthesized Polymers. Examination of Fluorescent Molecules as in situ Probes of Polymerization Reactions. Self-Etching, Polymerization-Initiating Primers for Dental Adhesion. Bioactive Polymeric Composites Based on Hybrid Amorphous Calcium Phosphates.

Glen S Kwon University of Wisconsin–Madison | UW · Division of Pharmaceutical Sciences