Polyamine Cell Signaling Physiology, Pharmacology, and Cancer Research

Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Part III: Polyamines in Cell Motility and Cell–Cell Interactions Part IV: Polyamine Homeostasis and Transport This book not only covers the current state-of-the-art findings relevant to cellular and molecular functions of polyamines, but also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting of polyamines and polyamine metabolism. These points are addressed by int- nationally recognized experts in their contributions to this book.

Part I. Polyamines in Signal Transduction of Cell Proliferation Polyamine Structure and Synthetic Analogs Patrick M. Woster Acute Increases in Intracellular Putrescine Lead to the Increase in Steady-State Levels of c-fos, c-jun, RING3, and Id-1 mRNAs Allan A. Ancheta, Leo Hawel, III, and Craig V. Byus Polyamine-Dependent Early Cellular Signals and Cell Proliferation Stina M. Oredsson Cellular Signals Mediating Growth Arrest After Polyamine Depletion Jian-Ying Wang Role of Polyamines in the Regulation of Chromatin Acetylation Cheryl A. Hobbs and Susan K. Gilmour Role of Polyamines in Regulation of Sequence-Specific DNA Binding Activity Sripriya Venkiteswaran, Thresia Thomas, and T. J. Thomas Polyamine Metabolism and the Hypertrophic Heart Lisa M. Shantz and Emanuele Giordano Influence of Polyamines on Breast Cancer Biology Andrea Manni Polyamines in Regulation of Prostatic Cell Growth Raymond G. Schipper, Vincent Cuijpers, Johannes C. Romijn, and Albert A. J. Verhofstad Polyamines in Kidney Biology Joseph Satriano Polyamines in Pulmonary Vascular Biology Jack W. Olson and Mark N. Gillespie Part II. Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Recent Advances in the Understanding of Mammalian Polyamine Catabolism: The Regulation and Potential Role of Polyamine Catabolism in Drug Response and Disease Processes Robert A. Casero, Jr., Alison V. Fraser, Tracy Murray-Stewart, Amy Hacker, Naveen Babbar, Jennifer Fleischer, and Yanlin Wang Cellular Signaling and Polyamines in the Control of Apoptosis in Intestinal Epithelial Cells Leonard R. Johnson and Ramesh M. Ray The Role of Ornithine Decarboxylase in Myc-Induced Tumorigenesis Jonas A. Nilsson and John L. Cleveland Protective Effect of Polyamines on NSAID-Induced Injury and Apoptosis Heather M. Wallace and Alun Hughes Role of Polyamines in the Control of the Immune Response in the Brain Denis Soulet and Serge Rivest Implication of Polyamines in Apoptosis of Immunoresponse Cells Rupesh Chaturvedi and Keith T. Wilson Polyamines and Cancer Ajit K. Verma Polyamine Pools and Cancer Prevention Eugene W. Gerner and David E. Stringer Part III. Polyamines in Cell Motility and Cell-Cell Interactions Polyamines and Cytoskeletal Regulation During Intestinal Epithelial Restitution Ramesh M. Ray and Leonard R. Johnson Regulation of Kv Channel Activity and Intercellular Junctions by Polyamines in Intestinal Epithelial Cells Jaladanki N. Rao and Jian-Ying Wang Polyamine Block of Kir Channels: Toward a Molecular Picture Harley T. Kurata and Colin G. Nichols Part IV. Polyamine Homeostasis and Transport Regulation of Ornithine Decarboxylase Expression Lo Persson Evidence for a Multistep Model for Eukaryotic Polyamine Transport Richard Poulin, Denis Soulet, Bruno Gagnon, Serge Rivest, and Marie Audette Bacterial and Eukaryotic Transport Systems Kazuei Igarashi and Keiko Kashiwagi Regulation of S-Adenosylmethionine Decarboxylase Colin Hanfrey Genetic Engineering of Polyamine Catabolism in Transgenic Mice and Rats Juhani Jänne, Leena Alhonen, Marko Pietilä, Tuomo A. Keinänen, Suvikki Suppola, Eija Pirinen, Mervi T. Hyvönen, Aki Järvinen, and Markku Laakso Index