Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement Modification of the Stratum Corneum

Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.

From the contents: THE ROLE OF SKIN HYDRATION IN PENETRATION ENHANCEMENT.- CHEMICAL PENETRATION ENHANCERS IN PENETRATION ENHANCEMENT.-Classification.- Mechanism.- Structure–Activity Relationship.- The Microenvironment Of The Enhancer Site Of Action.- Sulphoxides And Similar Chemicals.- Iminosulfuranes.- Azone  And Azone Analogues.- Fatty Acids, Fatty Acid Esters And Fatty Alcohols.- Alcohols And Glycols.- Terpenes And Essential Oils.- Transcutol Surfactants.- Nonionic Surfactants.- Natural Surfactants Of The Alkylpolyglucoside Type.- Sucrose Esters.- Pyrrolidones.- Chitosan.- Urea And Its Derivatives.- Transcarbams .- Amines And Amides.- Peptides.- Synergistic Effects.- CHEMICAL METHODS FOR TRANSDERMAL DELIVERY OF PEPTIDES AND PROTEINS.- Ultradeformable Vesicles.- Biphasic Vesicles For Transdermal Delivery Of Proteins.- CHEMICAL METHODS IN CUTANEOUS VACCINATION.- Vesicular Carriers In Transcutaneous DNA Vaccination.- Nanoparticles And Microparticles For Transcutaneous DNA Vaccination.- Chitosan-Nanoparticles In Gene Delivery.

Howard I. Maibach is Professor of Dermatology at the University of California, San Francisco. He is a leading authority in the fields of dermatotoxicology and dermatopharmacology, in which he has conducted much original research and written very extensively, with a total of more than 2,500 publications as lead or co-author. Professor Maibach has served on the editorial boards of more than 30 scientific journals and is a member of many professional societies, including the American Academy of Dermatology and the International Commission on Occupational Health. He has also been the recipient of numerous honors, both within the United States and overseas. Nina Dragicevic-Curic graduated from the University of Belgrade, Faculty of Pharmacy in 1999 and subsequently obtained an MSc and a PhD (summa cum laude, Dr. rer. nat.) in Pharmaceutical Technology from the University of Belgrade and the Friedrich-Schiller University, Jena, respectively. Dr. Dragicevic-Curic is an accredited Specialist in Pharmaceutical Technology. Since 2007 she has been responsible for the preparation of compounded drugs in pharmacies of the state pharmaceutical company “Apoteka Beograd” in Belgrade. She has published in a variety of international journals.