Nutrition and Immunology Principles and Practice

It is a pleasure to write the foreword to Nutrition and Table 1 Nutritional Status and Outcome of Infection Immunology: Principles and Practice. In fact, this book comes at a timely moment, when the impact of nutrition and Definite adverse outcome immunology is being widely felt because of the AIDS epi­ Measles, diarrhea, tuberculosis demic. This is particularly of note in Africa, where large Probable adverse outcome HIV, malaria, pneumonia sums of money are being spent on nutritional intervention Little or no effect programs in the hopes of improving immune responsive­ Poliomyelitis, tetanus, viral encephalitis ness. We should not forget, however, early advances in our Note: HIV= human immunodeficiency virus understanding of protein energy malnutrition (PEM). PEM can be used as a model to understand the nutritional basis of immunity, as well as the immunological influences on nutri­ tional status. Despite advances in agricultural production, tance. However, both in vitro studies and tests in laboratory PEM continues to affect hundreds of millions ofthe world's animals may have little resemblance to what is experienced population. The functional impact of undernutrition varies in humans under field conditions. from mild morbidity to life-threatening infection.

I. Nutritional Assesment. Application and Interpretation of Commonly Used Nutritional Assessment Techniques, Kenneth H. Brown. Evaluating Malnutrition: What Should the Physician Look For? Charles Halsted. Evaluation of the Immune System in the Nutritionally-at-Risk Host, Jonathan Powell, Andrea Borchers, Steven Yoshida, and M. Eric Gershwin. II. Specific Nutrient Requirements. (Normal Populations; Populations with Low Intakes, Including Teens, females, Elderly...). Caloric Intake: Sources, Deficiencies, and Excess - An Overview, Dean A. Troyer and Gabriel Fernandes. Protein and Amino Acids, Vernon R. Young. Specific Nutrient Requirements: Trace Elements, Janet C. King. Vitamins: Overview and Metabolic Functions, Robert Rucker. a-Lipoic Acid: The Metabolic Antioxidant, John K. Lodge and Lester Packer. Defining the Role of Dietary Phytochemicals in Modulating Human Immune Function, Harold Schmitz and Kati Chevaux. Dietary n-3 Polyunsaturated Fatty Acids Modulate T-Lymphocyte Activation: Clinical Relevance in Treating Diseases of Chronic Inflammation, Robert S. Chapkin, David N. McMurray, and Christopher A. Jolly. Nucleotides, George K. Grimble, Olwyn M. R. Westwood. III. Nutrient-Immune Interactions. Impact of Nutritional Status on Immune Integrity, Pam Fraker. Nutritional Modulation of Inflammation by Polyunsaturated Fatty Acids/Eicosanoids, Vincent A. Ziboh. IV. Clinical Issues. Immunological Considerations of Breast Milk, Bo Lonnerdal. Clinical Issues: Childhood Illnesses, Vaccinations, and Nutritional Status, Noel W. Solomons and Gerald T. Keusch. Protein Energy Malnutrition and Infectious Disease: Synergistic Interactions, Christopher A. Jolly and Gabriel Fernandes. Lipids, Inflammatory Cytokines, and Endothelial Cell Injury, Bernhard Hennig, Michal Toborek, and Gilbert A. Boissonneault. Nutrition and Allergy, Christopher Chang and M. Eric Gershwin. Adverse Reactions to Foods, Francesco Giuseppe Foschi, Lorenzo Marsigli, Francesco Chiappelli, Michelle A. Kung, Mauro Bernardi Giuseppe, and Francesco Stefanini. Perioperative Feeding: Nutrition and Immunity, Ronald R. Barbosa and Bruce M. Wolfe. Alcohol and Immune Function, Francesco Chiappelli, Michelle A. Kung, Giuseppe Francesco Stefanini, and Francesco Giuseppe Foschi. Cigaret Smoking, Substance Abuse, Nutritional Status, and Immune Function, Mari S. Golub. Nutrition, Immunity, and Alternative Medicine, Katherine Gundling, Andrea Borchers, and M. Eric Gershwin. Obesity and Immunity, Paul A. Davis and Judith S. Stern. Diabetes and Immunity, Manuel E. Baldeon and H. Rex Gaskins. Nutritional Modulation of Autoimmune Diseases, Claudio Galperin, Gabriel Fernandes, Ricardo M. Oliveira, and M. Eric Gershwin. Autoimmune Diseases of the Digestive Tract, Thomas P. Prindiville and Mary C. Cantrell. Diet and Allograft Rejection, Richard V. Perez and Steven Katznelson. Food Toxicology and Immunity, Linda Rasooly and Noel R. Rose. Interactions Between Nutrition and Immunity: Immunity Lessons from Animal Agriculture, Kirk C. Klasing and Tatiana V. Leshchinsky. Cancer and Nutrition, Carolyn K. Clifford. AIDS, William R. Beisel. Aging: Nutrition and Immunity, Simin Nikbin Meydani and Michelle Schelske Santos. Role of Nutrition in Common Oral Diseases, Cecilia Gorrel and Tiffany Bierer. The Anti Inflammatory Effects of Chinese Herbs, Plants, and Spices, Christopher Chang. The Influence of Probiotic Organisms on the Immune Response, Stephanie Blum, Yves Delneste, Anne Donnet, and Eduardo Jorge Schiffrin. Nutritional Effects on the Pathogen Genome and Phenotypic Expression of Disease. Melinda A. Beck. V. Future Directions. Whither Nutrition and Immunology Interactions Toward the Next Millennium? What is Past is Prologue, Noel W. Solomons. Index.