Neuropsychiatric Manifestations in Neurological Diseases

Psychiatric symptoms (or mood/emotional disturbances) are diverse in patients with neurological diseases, that include depression, anxiety, emotional incontinence, anger, fatigue, and apathy. These symptoms are common; more than 1/3 of the patients suffer from these symptoms. Unfortunately, they have been neglected because 1) unlike other neurological symptoms such as motor dysfunction, speech disturbances or visual field defect, these symptoms are not visible and difficult to be noticed unless they are specifically examined by a physician who is properly educated on this problem 2) they are often not regarded as neurological symptoms either by the patients or their caregivers 3) they are relatively poorly studied by both neurologists and psychiatrists, and accordingly, are unfamiliar to the physicians. Especially, although `depression’ is well known to physicians, other symptoms such as emotional incontinence, anger, fatigue or apathy are not appropriately assessed by physicians, and frequently misdiagnosed as depression. Moreover, there are difficulties in diagnosing depression in patients neurological diseases. For example, the individual items included in depression diagnosis such as sleep disturbances, appetite loss, or fatigue can result from neurological diseases or comorbid physical conditions in patients with neurological diseases. Therefore, a diagnosis of `depression’ should be made cautiously. Finally, it should be understood that the importance of different mood/ emotional syndromes differ among various neurological diseases; for instance, although emotional incontinence and anger occur in as many as 20-30 % of stroke patients, apathy and fatigue are more important symptoms than these for patients with neuro-degenerative disease.

In clinical practice, recognizing these symptoms is important because they negatively affect the patients’ quality of life, impair the functional recovery, increase the mortality, and increase the caregiver burden. Nevertheless, unlike other neurological symptoms such as motor/sensory dysfunction, and speech disturbances, they are relatively well managed mostly by pharmacological therapy such as selective serotonin re-uptake inhibitors (SSRI).

The phenomenology of these neuropsychiatric symptoms and related factors, pathophysiological mechanism, and treatment strategies should be properly educated for neurologists, psychiatrists and other physicians. The book is written by experts in this field to disseminate important knowledges to neurologists, psychiatrists, psychologists and other physicians and will eventually benefit patients with neurological diseases.

Part 1 Stroke.- 1 Depression and anxiety in stroke.- 2 Emotional incontinence in stroke.- 3 Anger or aggression in stroke.- 4 Fatigue in stroke.- 5 Other neuropsychiatric symptoms including psychosis in stroke.- Part 2 Alzheimer disease and other dementia.- 6 Depression  in dementia.- 7 Anxiety in dementia.- 8 Agitation in dementia.- 9 Apathy in dementia.- 10 Psychosis  in dementia.- Part 3 Seizures and epilepsy.- 11 Psychosis in epilepsy.- 12 Depression in epilepsy.- 13 Anger or aggression in epilepsy.- 14 Anxiety in epilepsy.- 15 Apathy in epilepsy.- Part 4 Other neurological disorders.- 16 Neuropsychiatric manifestations in Parkinson's disease and other movement disorders.- 17 Neuropsychiatric Manifestations of Amyotrophic Lateral Sclerosis.- 18 Neuropsychiatric manifestations in multiple sclerosis and other demyelinating diseases.- 19 Neuropsychiatric manifestations in traumatic brain injury.- 20 Neuropsychiatric manifestations in brain tumor.

Dr. Jong Sung Kim is an Honorary Professor of University of Ulsan, ASAN Medical Center, Seoul, South Korea.

He was the former president of Korean Neurological Association and Korean Stroke Society. He used to be a scientific committee member in major international conferences such as International Stroke Conference (ISC), European Stroke Conference (ESC), and Word stroke conferences (WSC).

He is currently the chief editor of `Journal of Stroke (impact factor 8.6), and an associate editor of Cerebrovasc Dis. He used to be an associate editor of Int J Stroke and J Stroke Cerebrovasc Dis. He has published 30 books or book chapters including `Intracranial Atherosclerosis’ (Karger, 2016), and `Posterior Circulation Stroke’ (Springer, 2021), and approximately 600 peer-reviewed scientific articles. His main academic interests include intracranial atherosclerosis, posterior circulation stroke, and imaging-based stroke treatment. In addition, he has had a special interest inneuropsychiatric manifestations of stroke including post-stroke depression, emotional incontinence, anger, apathy and fatigue. On this particular subject, he has published approximately 100 peer-reviewed scientific articles. He also wrote relevant chapters such as `Disturbances in the voluntary control of emotional expression after stroke’ in `Neuropsychiatric Symptoms of Cerebrovascular Diseases’(Ferro JM, ed, pp131-160, Springer, 2013). `Serotonin and Stroke‘ in Handbook of the Behavioral Neurobiology of Serotonin (Muller CP and Cunningham KA eds., pp989-1000, Academic Press, 2020),`Pseudo-bulbar Symptom or Emotional Incontinence’ in Stroke Syndromes (Caplan LR, ed, 4th ed, Cambridge, in press), and `Anger in Post-Illness: an Example of Stroke‘ in `Handbook of Anger, Aggression, and Violence (Victor R Preedy, ed, Springer Nature, in press). He has given lectures on this particular topic more than 20 times in domestic and international scientific conferences. To educate and facilitate research on this topic, he organized `Society of Mood and Other Behavioral Symptoms in Neurologic Diseases‘‚ and had served as the president for 10 years.