Neuropeptide Y: History and Overview.- PP, PYYand NPY: Synthesis, Storage, Release and Degradation.- NPY Receptor Subtypes and Their Signal Transduction.- Phylogeny of NPY-Family Peptides and Their Receptors.- Neuropeptide Y and Its Receptor Subtypes in the Central Nervous System: Emphasis on Their Role in Animal Models of Psychiatric Disorders.- Prejunctional Effects of Neuropeptide Y and Its Role as a Cotransmitter.- Neuroendocrine Actions Of Neuropeptide Y.- NPY: A Novel On/Off Switch for Control of Appetite and Reproduction.- Behavioral Effects of Neuropeptide Y.- NPY Effects on Food Intake and Metabolism.- Neuropeptide Yand Cardiovascular Function.- Neuropeptide Y and the Kidney.- NPY-Like Peptides, Y Receptors and Gastrointestinal Function.- NPY and Immune Functions: Implications for Health and Disease.- Transgenic and Knockout Models in NPY Research.- Structure-Activity Relationship of Peptide-Derived Ligands at NPY Receptors.- Structure-Activity Relationships of Nonpeptide Neuropeptide Y Receptor Antagonists.