Neuronal Networks of the Hippocampus

Important neurological techniques for the physiological reconstruction of a large biological neural network are presented.

The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Using a combined experimental-theoretical approach unique in neuroscience, the authors present important techniques for the physiological reconstruction of a large biological neuronal network. They begin by discussing experimental studies of the CA3 hippocampal region in vitro, focusing on single-cell and synaptic electrophysiology, particularly the effects a single neuron exerts on its neighbours. This is followed by a description of a computer model of the system, first for individual cells then for the entire detailed network, and the model is compared with experiments under a variety of conditions. The results shed significant light into the mechanisms of epilepsy, electroencephalograms, and biological oscillations and provide an excellent test case for theories of neural networks. Researchers in neurophysiology and physiological psychology, physicians concerned with epilepsy and related disorders, and researchers in computational neuroscience will find this book an invaluable resource.

Acknowledgments; Prologue; 1. The hippocampus in context; 2. Physiology of single neurons: voltage- and ligand-gated ionic channels; 3. Synaptic function and organization of the CA3 region; 4. The single-cell model; 5. Model of the CA3 network; 6. Collective behaviours of the CA3 network: experiment and model; 7. Collective behaviours of the CA3 network: spontaneous oscillations and synchronized synaptic potentials; 8. Field effects; 9. Theoretical approaches: mathematical neural networks; Appendix; Conclusion; Notes; References; Index.

The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Important neurological techniques for the physiological reconstruction of a large biological neural network are presented.