Macrophage Targeted Delivery Systems Basic Concepts and Therapeutic Applications

The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting. Macrophages have gained substantial attention as therapeutic targets for drug delivery considering their major role in health and regulation of diseases. Macrophage-targeted therapeutics have now added significant value to the lives and quality of life of patients, without undue adverse effects in multiple disease settings. We anticipate examining and integrating the role of macrophages in the instigation and advancement of various diseases. The major focus of the book is on recent advancements in various targeting strategies using delivery systems or nanocarriers followed by application of these nanocarriers for the treatment of macrophage associated disorders.

Macrophage Targeted Delivery Systems is primarily targeted to Pharmaceutical Industry & Academia, Medical & Pharmaceutical Professionals, Undergraduate & Post graduate students and Research Scholars, Ph.D, post docs working in the field of medical and pharmaceutical sciences.

Part I Anatomy, Physiology and Pharmacology of Macrophages.- Introduction to Anatomy and Physiology of Macrophages from Drug Delivery Perspective.- Introduction to Pharmacology of Macrophages from Drug Delivery Perspective.- Mechanisms and Ways of Macrophage Delivery.- Macrophage Associated Disorders: Pathophysiology, Treatment Challenges and Possible Solutions.- Understanding Macrophage Associated Diseases and Applications of Nano Drug Delivery Systems.- Part II Polymeric Nanoparticles for Macrophage Targeting .- Targeting of Macrophages: Basic and therapeutic Role of Polymeric Nanoparticles.- Polymeric Nanoparticles Based Drug and Gene Delivery to Macrophages.- Surface Modification of Nanoparticles for Macrophage Targeting.- Part III Lipid Nanoparticles for Macrophage Targeting.- Liposomes as Delivery System for Macrophage Targeting.- Solid Lipid Nanoparticles BasedDrug and Gene Delivery to Macrophages.- In vivo Fate of Colloidal Carriers Undergoing Macrophage Targeting.- Nanoparticle-based Theranostics for Macrophage-associated Diseases.- Part IV Targeting Macrophages for Treatment of Various Diseases.- Tumor Associated Macrophages as Therapeutic Target for Drug/immune Therapy of Cancer.- Macrophage Targeting for Therapy of Autoimmune Diseases.-  Macrophage Targeting for Therapy of Cardiovascular Diseases (CVD).- Macrophage targeting for therapy of intracellular infections.- Targeting Drugs and Nucleic Acids  to Macrophages for Therapy of Inflammatory Diseases.- Macrophage Targeted Chemotherapy for Tuberculosis and other Respiratory Disease..- Part V Specific Formulations and Clinical Trials on Macrophage Targeted Delivery.- Nano- and Microparticles Based Dry Powder Inhalers for Pulmonary Macrophage Drug Delivery.- Recent Trends in Clinical Studieson Macrophage  Targeted Delivery.- Future Directions and Challenges in Macrophage Targeting. 

Dr. Swati Gupta is an author and Professor of Pharmaceutics at Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India. She did her post-graduation and Ph.D. in Pharmaceutical Sciences with specialization in Pharmaceutics from Dr. Hari Singh Gour Vishwavidyalaya, Sagar, India. She has been awarded with GATE fellowship, Junior Research Fellowship by the University Grants Commission, New Delhi, and Senior Research Fellowship by the Council of Scientific and Industrial Research, New Delhi, India. Dr. Gupta has nearly twenty years of research/teaching experience. She has supervised 25 M.Pharm and 4 Ph.D. scholars. Dr. Gupta has over fifty publications to her credit published in international journals of high scientific impact and has contributed several chapters in many outstanding reference books. She is also the author of 5 books. Dr. Gupta has presented several research papers in international/national conferences and also served as the reviewer of several international journals like Molecular Pharmaceutics, Pharmaceutical Research, and Nature Scientific Report etc. She is also the recipient of prestigious young scientist awards, BOYSCAST fellowship of Department of Science & Technology, New Delhi for postdoctoral research in the USA, Bio-CARe Women Scientist award with a research grant of 22 Lakhs of Department of Biotechnology, New Delhi and Teachers Associateship in Research Excellence (TARE) Award of Science & Engineering Research Board. Her research interests include drug delivery using nanocarriers against intracellular infections, drug targeting, molecular pharmaceutics, and nanotoxicity.

Dr. Yashwant Pathak completed his education M.S., Ph.D. in Pharmaceutical Technology from Nagpur University, Nagpur, India and EMBA and MS Conflict Management from Sullivan University, USA. He is Associate Dean for Faculty Affairs and Tenured Professor, at the Taneja College of Pharmacy, University of South Florida. Tampa, Florida, USA.  With extensive experience in academia and industry, he has over 200 publications research papers, abstracts, chapters and reviews, 11 books in Nanotechnology and 6 in drug delivery systems, 12 in Nutraceuticals and several books in cultural studies (total over 50  edited volumes). His areas of research include drug delivery systems, nano biomaterials, nanotechnology applications in pharmacy, risk management and nanotechnology and Nutraceuticals. He has travelled extensively over 80 countries and is actively involved with many Pharmacy Colleges in different countries.  He is also adjunct professor at Faculty of Pharmacy, Airlangga University , Surabaya, Indonesia