Lu's Basic Toxicology Fundamentals, Target Organs, and Risk Assessment, Seventh Edition

Continuing a long tradition, Lu’s Basic Toxicology, Seventh Edition, combines relatively comprehensive coverage of toxic substances in food, air, and water with brevity, thereby continuing to serve as an updated introductory text for toxicology students and for those involved in allied sciences that require a background in toxicology. The new edition, which now becomes an edited work with contributions from experts around the globe, features four new chapters and a number of existing chapters that have been updated and expanded, notably those on mechanisms of toxic effects, conventional toxicity studies, the cardiovascular system, and risk assessment and regulatory toxicology. The book consists of four parts (Part I–Part IV) that provide guidance on principles of toxicology and testing procedures for toxicities as well as a concise, yet detailed, mechanism of both target organ and nontarget organ toxicities. The book is rounded off with a final section (Part IV) on the toxic effects of chemicals and risk assessment, giving toxicologists, both students and practicing professionals, the necessary tools to enhance their practice. This edition includes new chapters on Clinical Toxicology, Systems Toxicology, Chemicals and Children, and Toxicology of Reproductive Systems, providing the essentials of these topics in the same style as the other chapters in the book. With separate subject and chemical indexes, this is a useful, quick shelf reference for everyone working in toxicology today.

PART I: General Principles of Toxicology. History of Toxicology. Absorption, Distribution, and Excretion of Toxicants. Metabolism of Toxicants. Toxic Effects (Mechanisms of Toxic Effects). Modifying Factors of Toxic Effects. Conventional Toxicity Studies. Systems Toxicology. PART II: Testing Procedures for Nontarget Organ Toxicities. Carcinogenesis. Mutagenesis. Developmental Toxicology. Lactation. PART III: Target Organs and Systems. Toxicology of the Liver. Toxicology of the Kidney. Toxicology of the Immune System. Respiratory System Inhalation Toxicology. Toxicology of the Skin. Toxicology of the Eye. Toxicology of the Nervous System. Cardiovascular System. Toxicology of Reproductive Systems. Toxicology of the Endocrine System. PART IV: Toxic Substances and Risk Assessment. Food Additives and Contaminants. Toxicity of Pesticides. Nanotoxicology. Toxicity of Metals. Environmental Pollutants. Occupational Toxicology. Chemicals and Children. Clinical Toxicology. Risk Assessment and Regulatory Toxicology.

Byung-Mu Lee, BS, MS, MSPH, Dr PH, Division of Toxicology, College of Pharmacy, Sungkyunkwan University, South Korea, is associate editor of the Journal of Toxicology and Environmental Health, Part A, associate editor of Food and Chemical Toxicology, editorial board member of Environmental Health Perspectives, and advisory editor of Archives of Toxicology. He is currently the vice president of the International Association of Environmental Mutagenesis and Genomics Society (IAEMGS). He is the author of 230 papers, reviews, the Encyclopedia of Environmental Health, and 11 book chapters, as well as the coauthor of Lu’s Basic Toxicology, Sixth Edition (Informa, 2013). Prof. Lee has also been a research advisor of the Ministry of Food and Drug Safety, a committee advisor for the Ministry of Science, ICT, and Future Planning, the Ministry of Environment, and the Ministry of Human Health and Welfare in South Korea. He has been the president of the 13th International Congress of Toxicology (ICT XIII), the Korea Society of Toxicology (KSOT), and the Korea Environmental Mutagen Society (KEMS). He has been the vice president of the Asia Society of Toxicology (ASIATOX). He has organized eight workshops and three international symposia about toxicology, carcinogenesis, chemoprevention, endocrine disruption, and risk assessment. He has been a nominating committee member of the International Union of Toxicology (IUTOX) and deputy member of the Korean Pharmaceutical Society. Prof. Lee has received numerous awards, including the Young Scientist Award, Brookhaven Symposium (U.S.), the Yun Ho Lee Award of Scientific Merit (International Aloe Science Council (U.S.) and the Merit Award from the Minister, Ministry of Food Drug Safety (Republic of Korea). Prof. Lee’s research areas include: carcinogenesis, chemoprevention, endocrine disruption, molecular epidemiology, biomarkers, systems toxicology, and risk assessment/management. Sam Kacew, PhD, ATS, is an associate director of Toxicology, McLaughlin Centre for Population Health Risk Assessment at the University of Ottawa; professor of pharmacology, University of Ottawa; and scientist, Institute for Population Health, University of Ottawa. Prof. Kacew is a visiting professor at the following institutions: the University of Guildford in Surrey, England; a Colgate-Palmolive visiting professor at the University of New Mexico; Institute of Toxicology at National Taiwan University in Taipei, Taiwan; Joszef Fodor National Center of Public Health in Budapest, Hungary; Department of Occupational Health, Shanghai Medical University in Shanghai, China; Zhehjiang University in Hangzhou, China; Nanjing Medical University, Nanjing, China; and the Division of Toxicology at Sungkyunkwan University in Suwon City, Korea. Prof. Kacew is currently the editor-in-chief of the Journal of Toxicology and Environmental Health, Part A, Current Issue; editor-in-chief, Journal of Toxicology and Environmental Health, Part B, Critical Reviews; North American editor, Toxicological and Environmental Chemistry; associate editor of Toxicology and Applied Pharmacology; editor, Encyclopedia of Environmental Health; editor, Lu’s Basic Toxicology (Fourth and Fifth editions); and guest editor of a special issue of Toxicology and Applied Pharmacology entitled “Toxicological Reviews in Fetal Childhood Development.” He has edited several texts on pediatric toxicology and serves on several editorial boards. He has been a peer reviewer for the Environmental Protection Agency (EPA) on the Integrated Risk Information System (IRIS) documents, on the U.S. EPA Health Effects Assessment Summary Table (HEAST) chemicals, on the chemical-specific issue papers for the Superfund Technical Support Center (STSC) for the U.S. EPA, and has served on National Institutes of Health (NIH) grant study sections. Prof. Kacew is a member of the Board on Environmental Studies and Toxicology (BEST) of the National Academy of Sciences (U.S.) and is a member of the Science Advisory Council (SAC) of the National American Flame Retardant Association (NAFRA). Prof. Kacew has been a member of the board of trustees of Toxicology Excellence for Risk Assessment (TERA) and a member of the board of Review for Siloxane D5 appointed by the Minister of Environment of Canada. He has also been a member of the Committee on Toxicology of the National Academy of Sciences (NAS) of the United States and served as a chairman on the NAS Subcommittee on Iodotrifluoromethane; chairman on the NAS Subcommittee on Tetrachloroethylene; and a member of the NAS Subcommittees including Flame Retardants; Jet Propulsion Fuel-8, and Toxicologic and Radiologic Effects from Exposure to Depleted Uranium during and after Combat; and a member of the Advisory Expert Committee of the Canadian Network of Toxicology Centers. He served as a chairman of a U.S. EPA Panel on Peer Review Assessment of Toxicity Values for Total Petroleum Hydrocarbons, member of the Panel on the Beryllium Lympho