Introduction to Protein Science Architecture, Function, and Genomics

Written by a leading author in the field, Introduction to Protein Science provides a wide-ranging perspective on the study of protein structure and function in the context of bioinformatics and genomics. Opportunities for active learning are provided both in the text and online, enabling students to develop their problem solving skills.

Over the last century, the centrality of proteins to life on earth has become increasingly clear - from forming enzymes acting as catalysts for specific reactions, to crucial molecules such as antibodies in the immune system, and as signalling molecules between cells. In fact, the more they are studied, the more proteins continue to reveal new and exciting functions. Indeed, by studying amino acid sequences and protein structures it is even possible to unravel some of the mysteries of evolution itself. Introduction to Protein Science, 3rd edition provides a rich and broad introduction to this fascinating field by covering not only the structure and function of proteins, but also the methods and experimental techniques used to study them. The practical applications of our knowledge to diverse fields such as biotechnology and medicine are emphasized throughout, to help students appreciate the relevance of the subject to the real world. Active learning is encouraged by the provision of frequent exercises and problems, with further 'weblems' - web-based problems - on the Online Resource Centre. Online Resource Centre The Online Resource Centre to accompany Introduction to Protein Science features: For students: ·Answers to end-of-chapter exercises, and hints to end-of-chapter problems, so students can check their understanding. ·Rotating structures from the book to help students visualize proteins in 3D. ·Web-based problems for students to complete online. For registered adopters: ·Figures from the book in electronic format, ready to download

1 - Introduction
2 - Protein structure
3 - Protein structure determination
4 - Bioinformatics of protein sequence and structure
5 - Proteins as catalysts: enzyme structure, kinetics, and mechanism
6 - Proteins with partners
7 - Evolution of protein structure and function
8 - Protein folding and design
9 - Proteomics and systems biology

Arthur M. Lesk is Professor of Biochemistry and Molecular Biology at The Pennsylvania State University. He is the author of the highly successful Introduction to Bioinformatics, and Introduction to Genomics, both published by Oxford University Press.