Inhibitors of Protein Biosynthesis

1 Protein Synthesis and Translation Inhibitors.- 1 Introduction.- 2 Site of Action of Protein Synthesis Inhibitors.- 3 Selective Action of Translation Inhibitors.- 4 Translation of mRNA.- 2 Initiation.- 1 Introduction.- 2 Inhibitors of Recognition of the Initiator Substrate [Step (a)].- 3 Inhibitors of Initiator and mRNA Recognition [Steps (a) and (b)].- 4 Inhibitors of mRNA Recognition [Step (b)].- 5 Inhibitors of Subunit Joining [Step (c1)].- 6 Inhibitors of the Positioning of the Initiator in the Donor Site [Step (c2)].- 7 Unclassified Inhibitors of Initiation.- 3 Elongation.- 1 Introduction.- 2 Compounds Interfering with Aminoacyl -tRNA Recognition [Step (d)].- 3 Inhibitors of Peptide Bond Formation [Step (e)].- 4 Inhibitors of Translocation [Step (f)].- 5 Miscellaneous Inhibitors of Elongation.- 4 Termination.- 1 The Mechanism of Termination.- 2 Inhibitors of Termination.- 5 Miscellaneous Inhibitors of Translation.- 6 GTP Analogs.- 7 Selectivity and Specificity Reconsidered.- References.