In Vitro Percutaneous Absorption Principles, Fundamentals, and Applications

This book covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.

1. Preparation of Human and Animal Skin 2. Diffusion Cell Design 3. A Flow-Through Diffusion Cell 4. Individual and Regional Variation with In Vitro Percutaneous Absorption 5. Receptor Fluids 6. Assessment of Vehicle Factors Influencing Percutaneous Absorption 7. Cutaneous Metabolism 8. Effect of Occlusion 9. Skin Storage Conditions 10. In Vitro Absorption through Damaged Skin 11. Localization of Drugs in the Skin 12. Expression of Absorption Data 13. The LPP Theory of Skin Penetration Enhancement 14. In Vitro Percutaneous Absorption of Alachlor and Atrazine 15. In Vivo — In Vitro Correlations for Hydrophobic Compounds 16. In Vitro Absorption: Skin Flap Model 17. Percutaneous Penetration from Soil: Inhibition or Enhancement? 18. Short-Term In Vitro Skin Exposure 19. Protocol for In Vitro Percutaneous Absorption Studies 20. Finite Dose In Vitro Percutaneous Permeation Based on the Diffusion Model: Estimation of Pharmacokinetic Parameters and Prediction of the Pharmacokinetic Profiles 21. Effect of Sodium Lauryl Sulfate-Induced Skin Irritation on In Vitro Percutaneous Absorption

Robert L. Bronaugh, Howard I. Maibach.