Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Dr. Sajal Chakraborti is a Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of oxidant-mediated signaling in the pathogenesis of a variety of diseases. Dr. Chakraborti did is PhD from Calcutta University (1982) and DSc from Kalyani University (2004). He also did postdoctoral research at the Johns Hopkins University, Baltimore; University of Utah Health Sciences Center, Salt Lake City; and New York Medical College, New York, as a Fulbright Fellow (1987–1990). He received Department of Biotechnology (Govt. of India) Senior Overseas Research Award for his research at the University of Florida, Gainesville (1998–1999). He has been engaged in teaching and research in Biochemistry for the past 40 years. He has published over 120 original research papers, 22 book chapters, and 15 review articles. He also edited 12 books published by Springer.