Handbook of Metallonutraceuticals

The nutritional and medicinal value of metals, such as zinc, calcium, and iron, has been known in traditional medicine for a long time. Other metals, such as silver and gold, may also have therapeutic and health benefits. Ancient medicines have long incorporated their use in the treatment of diseases, and they have also more recently been explored for treatment in allopathic medicine, birthing the concept of metallonutraceuticals. The challenge of using metals in the human body is to find forms that are safe and effective.Handbook of Metallonutraceuticals presents basic concepts related to the nutritional and therapeutic use of metals, product development strategies, and some ideas ready to be applied for condition-specific metallonutraceuticals. The book begins with an overview of the nutraceuticals field and the need for metallonutraceuticals. It considers the roles of various metals in metabolism, reviews the ethnopharmacology and ethnomedicine of metals, and covers the characterization and possible properties of metallonutraceuticals. It also examines bioavailability and drug interactions, and therapeutic applications of nanometals including use as imaging agents, in cancer diagnosis and treatment, as antibacterials and antivirals, in ocular disease, and in neurodegenerative diseases.The book explores the use of metals in traditional Chinese medicine, potential applications for metalloenzymes, the use of nanosilver in nutraceuticals, and the potential of gold nanoparticles as a drug delivery system. In addition, it addresses intellectual property rights and regulatory considerations regarding metallonutraceuticals. Using an interdisciplinary approach, this user-friendly text provides a knowledge base and inspiration for new research in this exciting field.

Concept, Definition, and Need for MetallonutraceuticalsJayant Lokhande and Yashwant PathakRoles of Metals in MetabolismJatin Shah and Jayant LokhandeEthnopharmacology and Ethnomedicine of MetalsJayant Lokhande, Shriniwas Samant, Ganesh Shinde, and Yashwant PathakCharacterization of MetallonutraceuticalsJayant Lokhande and Yashwant PathakCharacterization Bioavailability and Drug Interactions of MetallonutraceuticalsCharles PreussTherapeutic Applications of NanometalsAmy Broadwater, Bhaskar Mazumder, and Yashwant PathakMetallonanotherapeutics for Neurodegenerative DiseasesKomal Vig and Shivani SoniNanometals and Complexes in Cancer Diagnosis and TherapySajid Bashir, Srinath Palakurthi, Hong-Cai Zhou, and Jingbo LiuApplication of Metals in Traditional Chinese MedicineBhaskar Mazumdar, Shufeng Zhou, Jiayou Wang, and Yashwant PathakMetalloenzymes: Relevance in Biological Systems and Potential ApplicationsRavi Ramesh PathakApplication of Nanosilver in NutraceuticalsPranab Jyoti Das, Bhasker Mazumder, and Charles PreussRegulatory Pathways and Intellectual Property Rights for MetallonutraceuticalsVishal Kataria, Jayant Lokhande, Vrinda Vedi, and Yashwant PathakGold Nanoparticles: A Promising Nanometallic Drug Delivery System with Many Therapeutic ApplicationsAnastasia Groshev, Danielle Dantuma, Vaibhav Alandikar, Samuel Rapaka, Yashwant Pathak, and Vijaykumar SutariyaIndex

Yashwant V. Pathak, Ph.D., is currently the associate dean for faculty affairs at the newly launched College of Pharmacy, University of South Florida, Tampa. With extensive experience in academia and industry, Dr. Pathak has over 120 publications, research papers, abstracts, book chapters, and reviews to his credit. He has also coedited six books on nanotechnology and drug delivery systems, four books on nutraceuticals, and several books on cultural studies. Dr. Pathak is the holder of one patent.Jayant Lokhande, M.D., is an expert in botanical drug product (BDP) and biotechnology business management with integrated economics and regulatory aspects. He has worked for several nutraceuticals companies in the United States and India and has formulated successful strategies for marketing nutraceuticals worldwide. He has significant clinical experience in botanical drugs and the application of nutraceuticals in chronic diseases. He recently started his own company Indus Inc and Indus Extracts in the United States, for which his responsibilities include business analysis, product development, and technical marketing and sales.