Handbook of Macrocyclic Supramolecular Assembly

This handbook presents recent advances and offers a comprehensive reference resource covering the developments in and applications of macrocyclic supramolecular assembly, with a focus on their construction, structural characters and biological functions. The main topics addressed include: 

1. Construction and structure of macrocyclic supramolecular assembly – key building blocks, construction methods, structural motifs, and stimuli responsive control
2. Approach and technology – controllable synthesis, molecular recognition, spectral and thermodynamic study, supramolecular assembly at interfaces, orthogonal self-assembly, the supramolecular organic framwork (SOF), molecular induced aggregation, supramolecule assisted 3D printing, theoretical calculation and molecular simulation 
3. Biological applications – chemical and biological sensing, theranostic tools, molecule/ion channels, drug/gene delivery, supramolecule assisted biomolecule production, supramolecule assisted transmembrane transport, supramolecule assisted immunity regulation, supramolecule-based medicinal drug, etc. 

Section 1. Supramolecular Assemblies Based on Crown Ethers and Cyclophanes.- Chapter 1. Water-Soluble Aromatic Crown Ethers: from Molecular Recognition to Molecular Assembly.- Chapter 2. Polypseudorotaxanes Constructed by Crown Ethers.- Chapter 3. Host-Guest Chemistry of A Macrocycle Containing p Systems Namely Cyclobis(paraquat-p-phenylene).- Chapter 4. Mechanically Selflocked Molecules.- Chapter 5. Photo-luminescent Crown Ether Assembly. Section 2. Supramolecular Assemblies Based on Macrocyclic Arenes.- Chapter 1. Triptycene Derived Macrocyclic Arenes: from Calixarenes to Helicarenes.- Chapter 2. General Introduction of Some Emerging Macrocyclic Arenes Related to Calixarenes and Pillararenes.- Chapter 3. Macrocyclic Amphiphiles for Nanomedicine.- Chapter 4. Preparation of Biosensor Based on Supermolecular Recognizaiton.- Chapter 5. Application of Anion-Pi Interaction on Supramolecular Self-Assembly.- Chapter 6. Functional Rotaxanes: from Synthetic Methodology to Functional Molecular  Materials.- Chapter 7. Biphen[n]arenes: Synthesis and Host-Guest Properties.- Chapter 8. Pillararene-based Supramolecular Polymer. Section 3. Supramolecular Assemblies Based on Cyclodextrins.- Chapter 1. Functionalized Cyclodextrins and Their Applications.- Chapter 2. Cyclodextrin Polyrotaxanes: Synthesis, Analytics and Functions.- Chapter 3. Cyclodextrin Hybrid Inorganic Nanocomposites for Molecular Recognition, Selective Adsorption and Drug Delivery.- Chapter 4. Photoresponsive Supramolecular Assembly with Biological Function.- Chapter 5. Cyclodextrin-based Supramolecular Hydrogel.- Chapter 6. Supramolecular Chiral Photochemistry.- Chapter 7. Construction and Functions of Supramolecular Cyclodextrin Polymer.- Chapter 8. Construction of Cyclodextrin-based Magnetic Supramolecular Assemblies and Its Regulation of Cell Mobility.- Chapter 9. Supramolecular Assemblys Based on Multi-Charge Cyclodextrin Induced Aggregation. Section 4. Supramolecular Assemblies Based on Cucurbiturils.- Chapter 1. Stimuli Responsive Self-Assembly Based on Macrocyclic Hosts and Biomedical Applications.- Chapter 2. Modulation of Chemical and Biological Properties of Biomedically Relevant Guest Molecules by Cucurbituril-type Hosts.- Chapter 3. Self-Assembled Two-Dimensional Organic Layers in Solution Phase.- Chapter 4. Modified Cucurbiturils with Various Ring Size: Synthesis.- Chapter 5. Modified Cucurbiturils with Various Ring Size: Assembly.- Chapter 6. Modified Cucurbiturils with Various Ring Size: Functions.- Chapter 7. Biological Systems Involving Cucurbituril.- Chapter 8. Cucurbituril-based Pseudorotaxanes and Rotaxanes.- Chapter 9. Construction of Supramolecular Networks Based on CB8. Section 5.   Supramolecular Assemblies Based on Other Macrocycles.- Chapter 1. Supramolecular Catalysis Using Functional Organic Macrocycles and Molecular Cages.- Chapter 2. Porphyrins and Porphyrinoids: Syntheses, Structures, and Properties.- Chapter 3. Protein Self-Assembly: Strategies and Applications.- Chapter 4. Peptide Tectonics: towards Biomimetic and Bioinspired Soft Materials.- Chapter 5. Naphthol-based Macrocycles.- Chapter 6. Carbohydrate-based Macromolecular Self-Assembly.- Chapter 7. in vivo Self-Assembly of Polypeptide-based Nanomaterials.- Chapter 8. Construction of Well-Defined Discrete Metallacycles and Their Biological Applications. Section 6.   Some Important Approaches in Macrocycle-based Supramolecular Chemistry.- Chapter 1. Molecular Simulations of Supramolecular Architectures.- Chapter 2. Thermodynamic Studies of Supramolecular Systems.- Chapter 3. Spectral Studies of Supramolecular Systems.- Chapter 4. Artificial Host Molecules Modifying Biomacromolecules.- Chapter 5 Controllable Synthesis of Polynuclear Metal Clusters within Macrocycles.- Chapter 6 Integrating Macrocyclic Rings into Functional 3D Printing Materials.- Chapter 7 Molecular Recognition with Helical Receptors.- Chapter 8 Supramolecular Interface for Biochemical Sensing Applications.- Chapter 9 Supramolecular Functional Complexes Constructed by Orthogonal  Self-Assembly.- Chapter 10 Aggregation Induced Emission of Macrocycle-based Assemblies.- Chapter 11 Application of Rare Earth  Metal Complexes in Macrocycle-based Assemblies.- Chapter 12 Two Dimensional Supramolecular Framwork Based on Host-Guest Self-Assembly. Section 7.   Biological Applications.- Chapter 1. Theranostic Supramolecular Vesicle Systems.- Chapter 2. Host–Guest Sensing by Nanopores and Nanochannels.- Chapter 3. Highly Selective Ultrafast Proton Transport by Synthetic Unimolecular Proton Channels.- Chapter 4.Drug/Gene Delivery Platform Based on Supramolecular Interactions: Hyaluronic Aicd and Folic Acid as Targeting Units.- Chapter 5. Self-Assembling Peptides for Vaccine Development and Antibody Production.- Chapter 6. Supramolecules Assisted Transportof Ions and Molecules through Lipid Bilayers.- Chapter 7. Construction and Biomedical Applications of Macrocycle-based Supramolecular Topological Polymers.- Chapter 8. Supermolecules as Medicinal Drugs.- Chapter 9. Nanoscaled Cyclodextrin Supermolecular System for Drug and Gene Delivery.- Chapter 10. Immunity Regulation by Cyclodextrin-based Supramolecular Assembly.- Chapter 11. Industrial Application of Cyclodextrin.

Yu Liu is a professor at Nankai University. He received his Ph.D. from Himeji Institute of Technology, Japan, in 1991. Then, he spent about 2 years (1991–1992) as postdoctoral fellow at Lanzhou Institute of Chemical Physics. In 1993, he moved to Nankai University as a professor and got the special government allowances of the State Council. Prof. Liu obtained the support of National Outstanding Youth Fund in 1996 and is now the specially appointed professor of Cheung Kong Scholars Programme. He has made a great deal of contribution to the supramolecular chemistry of crown ether, cyclodextrin, and calixarene, and is the contributor of 8 books and more than 500 articles (h-index: 61). Prof. Liu won a Second Class Award of Natural Science from Chinese Academy of Science in 1990; a Second Class Award of Scientific and Technological Progress from Ministry of Education in 1998; three times First Class Award of Natural Science of Tianjin in 2000, 2005, and 2015; a Second Class Awardof State Natural Science Prize in 2010, and a Special Grade Award of Baogang Outstanding Teacher in 2003.

Heng-Yi Zhang born in Anhui Province of China, in 1965, is a professor of Nankai University (Tianjin, China). He received his M.S. degree from Anshan Research Institute of Thermal Energy in 1994 andhis Ph.D. from Nankai University in 2000. In the same year, he became a lecturer of Nankai University and a professor in 2005. His current research interests focus on molecular recognition and molecular assembly based on the macrocyclic compounds including crown ether, cyclodextrin, and cucurbituril. Prof. Zhang is the contributor of 4 books and more than 130 research papers. In addition, He won one Second Class Award of State Natural Science Prize in 2010, two First Class Award of Natural Science Prize by Tianjin in 2005 and 2015, and one Second Class Award of Natural Science Prize by Ministry of Education in 2002.