Handbook of Lipid Membranes Molecular, Functional, and Materials Aspects

This handbook provides a unique overview of lipid membrane fundamentals and applications. The fascinating world of lipids that harbor and govern so many biological functionalities are discussed within the context of membrane structures, interactions, and shape evolution. Beyond the fundamentals in lipid science, this handbook focuses on how scientists are building bioinspired biomimetic systems for applications in medicine, cosmetics, and nanotechnology. Key Features: Includes experimental and theoretical overviews on the role of lipids, with or without associated biomolecules, as structural components imparting distinct membrane shapes and intermembrane interactions Covers the mechanisms of lipid-membrane curvature, by peptide and protein binding, and the roles of signalling lipids and the cytoskeleton in plasma membrane shape evolution Covers advanced X-ray and force measurement techniques Discusses applications in biomedicine, cosmetics, and nanotechnology, including lipid vectors in nucleic acid, drug delivery in dermal applications, and lipid-based sensors and artificial biointerfaces Covers artificial membranes from block copolymers, synthetic copolypeptides, and recombinant proteins Includes an exciting section that explores the role of lipids in the origin of life in hydrothermal conditions This book is a highly informative companion for professionals in biophysics, biochemistry, physical chemistry, and material and pharmaceutical sciences and bioengineering.

Preface Editors Contributors Chapter 1 A Short History of Membrane Physics Erich Sackmann and Avinoam Ben-Shaul Chapter 2 Structures and Interactions in Freely Suspended Multilayer Membranes and Dilute Lamellar Fluid Membranes from Synchrotron X-Ray Scattering Gregory S. Smith and Cyrus R. Safinya Chapter 3 Structures of Lipid Membranes: Cubic and Inverse Hexagonal Phases Charlotte E. Conn and John M. Seddon Chapter 4 Structure of Lipid Membranes by Advanced X-Ray Scattering and Imaging Tim Salditt Chapter 5 Adhesion Protein Architecture and Intermembrane Potentials: Force Measurements and Biological Significance Deborah E. Leckband Chapter 6 Charged Membranes: Poisson·Boltzmann Theory, the DLVO Paradigm, and Beyond Tomer Markovich, David Andelman, and Rudolf Podgornik Chapter 7 Membrane Shape Evolution In Vitro Alexandra Zidovska Chapter 8 Mechanisms of Membrane Curvature Generation by Peptides and Proteins: A Unified Perspective on Antimicrobial Peptides Michelle W. Lee, Nathan W. Schmidt, and Gerard C. L. Wong Chapter 9 Lipid Membrane Shape Evolution and the Actin Cytoskeleton David R. Slochower, Yu-Hsiu Wang, Ravi Radhakrishnan, and Paul A. Janmey Chapter 10 Effects of Osmotic Stress on Topologically Closed Membrane Compartments James C. S. Ho, Bo Liedberg, and Atul N. Parikh Chapter 11 Cationic Liposomes as Spatial Organizers of Nucleic Acids in One, Two, and Three Dimensions: Liquid Crystal Phases with Applications in Delivery and Bionanotechnology Cyrus R. Safinya, Kai K. Ewert, Youli Li, and Joachim O. Rädler Chapter 12 Lipids in DNA, RNA, and Peptide Delivery for In Vivo Therapeutic Applications Tyler Goodwin and Leaf Huang Chapter 13 Electrostatics of Lipid Membranes Interacting with Oppositely Charged Macromolecules Guilherme Volpe Bossa, Klemen Bohinc, and Sylvio May Chapter 14 Lipid-Based Bioanalytical Sensors Marta Bally, Hudson Pace, and Fredrik Hook Chapter 15 Lipids in Dermal Applications: Cosmetics and Pharmaceutics Jerome Bibette and Abdou Rachid Thiam Chapter 16 Supported Lipid Bilayers Theo Lohmuller, Bert Nickel, and Joachim O. Rädler Chapter 17 Artificial Membranes Composed of Synthetic Copolypeptides Timothy J. Deming Chapter 18 Synthetic Membranes from Block Copolymers, Recombinant Proteins, and Dendrimers Daniel A. Hammer, Zhichun Wang, Ellen Reed, Chen Gao, and Kevin B. Vargo Chapter 19 Amphiphilic Self-Assembly and the Origin of Life in Hydrothermal Conditions Christos D. Georgiou and David W. Deamer Index

Cyrus R. Safinya is professor of physics at the University of California, Santa Barbara, USA. Joachim O. Rädler is professor of experimental physics at Ludwig-Maximilians-Universität München, Germany.