The significant impact of the renin-angiotensin system (RAS) on basic research and its clinical relevance are reflected by the flourishing publication of original and review research articles; by the appearance of whole issues of journals dedicated to the RAS; and by specialist books on the RAS. In such a rapidly evolving environment, publications that span the spectrum from basic research to the bedside, fill a particularly valuable niche for clinicians and researchers alike.
The primary aim of this book is to provide a topical and timely forum for the critical appraisal of an area of RAS research that is expanding rapidly. In this respect, a collection of thirteen chapters from distinguished and world-class experts in the field has been presented on the contemporary research of the RAS and their implications in human disease. It is clear that outstanding and stellar work on the novel roles of local RAS and their potential clinical application is being done in laboratories and clinics across the globe. This volume should be of general interest to the readership of our "Proteases in Biology and Disease" book series, as well as being a comprehensive book for basic scientists, clinicians and newcomers to this field. TOC:Corresponding Authors. Preface. 1: Role of ACE, ACE2 and Neprilysin in the kidney.- 2: ACE Inhibition in Heart Failure and Ischaemic Heart Disease.- 3: Proteases of the Renin-Angiotensin System in Human Acute Pancreatitis.- 4: The Renin-Angiotensin System in Pancreatic Stellate Cells: Implications in the Development and Progression of Type 2 Diabetes Mellitus.- 5: Renin-Angiotensin System Proteases and the Cardiometabolic Syndrome: Pathophysiological, Clinical and Therapeutic Implications.- 6: The Role of the Renin-Angiotensin System in Hepatic Fibrosis, 7:The Renin-Angiotensin System in the Breast.- 8: Role of Local Renin-Angiotensin System in the Carotid Body and in Diseases.- 9: Bone Homeostasis: An Emerging Role for the Renin-Angiotensin System.- 10: The Renin-Angiotensin System and its Inhibitors in Human Cancers.- 11: The Skeletal Muscle RAS in Health and Disease.- 12: Local Angiotensin Generation and AT2 Receptor Activation.- 13: ADAMs as Mediators of Angiotensin II Actions.- Index.
