Foot and Mouth Disease Current Perspectives

Renewed interest in foot-and-mouth disease (FMD) research worldwide has led to an increase in the amount of scientific data generated. This comprehensive volume will help keep the FMD researchers up-to-date with all the latest developments. Interdisciplinary in approach, this book is the first to provide a coherent picture of the emerging strategies for diagnosis and control. With contributions from leading international FMD researchers, it presents exhaustive coverage of the entire subject. Topics include genome organization, virus RNA translation and replication, proteinases, virus particles, clinical signs of FMD, viral persistence, host range, immunology, quasispecies dynamics and evolution, vaccines, and much more.

The shock following the recent outbreak of foot-and-mouth disease (FMD) in the UK dispelled the notion that this disease was permanently under control and could be forgotten. FMD proved to be an endemic disease in many countries and continues to pose a major threat to animal health worldwide. The development of more effective and socially acceptable diagnosis and control measures is essential to effectively combat this devastating virus. Foot and Mouth Disease: Current Perspectives benefits researchers by presenting the latest developments resulting from the upsurge in data concerning this disease. Interdisciplinary in its approach, this book offers the first coherent picture of emerging strategies for diagnosis and control. With contributions from respected FMD researchers worldwide, this volume provides comprehensive coverage of the entire spectrum of FMD issues. Topics include genome organization, translation and replication of FMD virus RNA, proteinases, virus particles, clinical signs of FMD, and much more. This book delivers essential information for everyone with an interest in FMD, such as virologists, molecular biologists, biotechnologists, veterinarians, and pharmaceutical and biotech researchers.

Stepping Stones in Foot-and-Mouth Research: A Personal ViewF. BrownGenome Organization, Translation and Replication of Foot-and-Mouth Disease Virus RNAGraham J. Belsham and Encarnacion Martinez-SalasFoot-and-Mouth Disease Virus ProteinasesMartin D. Ryan, Michelle L.L. Donnelly, Mike Flint, Vanessa M. Cowton, Garry Luke, Lorraine E. Hughes, Caroline Knox and Pablo de FelipeStructure of Foot-and-Mouth Disease Virus ParticlesCristina Ferrer-Orta and Ignacio FitaClinical Signs of Foot-and-Mouth DiseaseAlex DonaldsonPersistence of Foot-and-Mouth Disease VirusJ.S. SaltMolecular Aspects of Foot-and-Mouth Disease Virus Virulence and Host Range: Role of Host Cell Receptors and Viral FactorsBarry Baxt and Elizabeth RiederImmunology of Foot-and-Mouth DiseaseKenneth C. McCullough and Francisco SobrinoFunctional and Structural Aspects of the Interaction of Foot-and-Mouth Disease Virus with AntibodiesMauricio G. Mateu and Nuria VerdaguerQuasispecies Dynamics and Evolution of Foot-and-Mouth Disease VirusEsteban Domingo, Carmen M. Ruiz-Jarabo, Armando Arias, Juan Garcia-Arriaza and Cristina EscarmisModern Inactivated Foot-and-Mouth Disease (FMD) Vaccines: Historical Background and Key Elements in Production and UseS.J. BartelingFoot-and-Mouth Disease Virus Peptide VaccinesDavid J. RowlandsMathematical Models of the Epidemiology and Control of Foot-and-Mouth DiseaseMark E.J. WoolhouseNatural Habitats in which Foot-and-Mouth Disease Viruses are MaintainedWilna Vosloo and Gavin R. ThomsonDiagnosis and Control of Foot-and-Mouth DiseaseR.P. KitchingControl of Foot-and-Mouth Disease: Role of International OrganizationsJ. Blancou, Y. Leforban, J.E. PearsonOverview of Foot-and-Mouth Disease and its Impacts as a Re-Emergent Viral InfectionBrian W.J. Mahy

Esteban Domingo, Francisco Sobrino