Fluorine Magnetic Resonance Imaging

Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.

TECHNICAL ISSUESPulse Sequence Considerations and SchemesCornelius Faber and Florian SchmidAdvanced Detection Techniques and Hardware: Simultaneous 19F/1H MRILingzhi Hu, Jochen Keupp, Shelton D. Caruthers, Matthew J. Goette, Gregory M. Lanza, and Samuel A. WicklineHyperpolarization for Signal Enhancement in Fluorine MR ApplicationsUte Bommerich, Johannes Bernarding, Denise Lego, Thomas Trantzschel, and Markus Plaumann19F IMAGING AGENTSActive Targeting of Perfluorocarbon NanoemulsionsSebastian Temme, Christoph Grapentin, Tuba Güden-Silber, and Ulrich FlögelResponsive Probes for 19F MRS/MRIAneta Keliris, Klaus Scheffler, and Jörn EngelmannINFLAMMATION IMAGINGImaging Acute Organ Transplant Rejection with 19F MRIT. Kevin Hitchens, Lesley M. Foley, and Qing YeCardiac DiseaseRuud B. van Heeswijk, Christine Gonzales, and Juerg SchwitterMONITORING OF SPECIFIC CELL POPULATIONSTracking Lymphocytes in vivoGhaith Bakdash and Mangala SrinivasTracking of Dendritic CellsSonia Waiczies, MinChi Ku, and Thoralf NiendorfNeural Stem CellsMarkus Aswendt, Philipp Boehm-Sturm, and Mathias HoehnPHARMACOLOGYFluorinated Natural Compounds and Synthetic DrugsThoralf Niendorf, Yiyi Ji, and Sonia WaicziesOTHER BIOMEDICAL APPLICATIONSImaging of the Respiratory SystemMarcus J. Couch, Alexei V. Ouriadov, and Mitchell S. AlbertTracking of Capsules and Catheters in the Human Gastrointestinal TractAndreas Steingötter and Tobias HahnPERSPECTIVESPerfluorocarbon Theranostic Nanomedicines: Pharmaceutical Scientist’s PerspectiveJelena M. Janjic and Sravan K. Patel

Ulrich Flögel is professor of experimental cardiovascular imaging at the Heinrich Heine University of Düsseldorf, Germany. His research focuses on the interplay of function, energetics, metabolism, and inflammation and its role in the development of cardiovascular diseases using innovative multinuclear MRI/MRS techniques. Eric Ahrens is professor of radiology and director of Stem Cell Molecular Imaging at the University of California, San Diego. His research focuses on adapting MRI to visualize cellular and molecular events in vivo. His lab is developing novel materials and methods for MRI-based cell tracking that are used for monitoring cell therapies and cellular immunological processes.