Endocrine Toxicology, Third Edition

With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology’s increased importance in environmental safety issues due to legislative directives established over the past ten years. Covering all principal areas of EPA concern, Endocrine Toxicology, Third Edition provides: putative endocrine disruptors and mechanisms of endocrine toxicity the history and status of the regulatory process mechanisms of toxic effects in various hormonal systems comparisons of the endocrine responses in humans, livestock, and wildlife testing methods in mammalian, fish, avian, and amphibian models valuable insight into the approaches of various personnel in the field, including: government officials who make and oversee policy; scientists in charge of development and validation of testing methods; basic researchers who identify toxic mechanisms; and manufacturers responsible for environmentally benign product certification

PrefaceContributorsTesting and MethodsThe U.S. EPA’s Tier 1 Screening Battery for Endocrine Disruptor Compounds J. Charles Eldridge and Susan C. LawsThe Effects of Endocrine Disrupting Chemicals on Pubertal Development in the Rat: Use of the EDSP Pubertal Assays as a Screen Tammy E. Stoker and Leah M. ZorrillaMale Reproductive Endpoints and the Rodent Hershberger Assay Tomoya YamadaOverview of USEPA Tests with Aquatic Vertebrates for Detecting and Assessing Endocrine Disrupting Chemicals Gerald T. Ankley, Sigmund J. Degitz, Mary L. Haasch, Kathleen M. Jensen, Rodney D. Johnson, Allen W. Olmstead, Joseph E. Tietge, and Geraldine CripeMolecular ToxicologyModulation of Estrogen Receptor Signaling by Endocrine Disrupting Chemicals Derek V. Henley and Kenneth S. KorachAndrogen Receptor Binding and Transactivation Assays Identify Environmental Chemicals as Endocrine Disruptors Terry R. BrownStructure-Activity Modeling of Endocrine Disruptors James DevillersAryl Hydrocarbon Receptor Ligands: Toxic, Biochemical, and Therapeutic Effects Stephen Safe, Gayathri Chadalapaka, and Indira JutooruMammalian EffectsThe Impact of Centrally Acting Pesticidal/Environmental Toxicants on the Neuroendocrine Regulation of Reproductive Function in the Female Rodent: Relevance to Human Reproductive Risk Assessment Jerome M. Goldman and Ralph L. CooperTime-Dependent Embryotoxicity of the Endogenous Luteolysin Prostaglandin F2a in Ruminants E. Keith InskeepMetal Toxicity in Mammalian Reproduction Michael C. Henson, Martina Piasek, P. Jorge Chedrese, and V. Daniel CastracaneWildlife EffectsOverview of Endocrine Disruptor Ecotoxicity in Wildlife Gerald A. LeBlancAvian Endocrine Toxicology Leslie W. Touart and Mary Ann OttingerEndocrine-Disrupting Compounds in Aquatic Ecosystems Stephen J. Jordan, William H. Benson, Christy M. Foran, Erin R. Bennett, and Erin M. SnyderThe Hypothalamic-Pituitary-Gonadal Axis in Anuran Amphibians Werner Kloas and Ilka LutzPolicy and ManagementImpact of Endocrine Disruptor Policies and Regulations James C. Lamb and Karyn L. HentzImpact of Endocrine Disrupting Compounds to the Water Industry Benjamin D. Stanford, Mark J. Benotti, and Shane A. SnyderIndex

Eldridge, J. Charles; Stevens, James T.