Emerging Trends in Cell and Gene Therapy

Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies. Representing the combined effort of several leading international research and clinical experts, this book, Emerging Trends in Cell and Gene Therapy, provides a complete account on and brings into sharp focus current trends and state-of-the-art in important areas at the interface of cell- and gene-based therapies. This book addresses the current fragmented understanding regarding these two research areas and fills the vast unmet educational need and interest of both students and researchers in academia and industry.

Main features of the book:

·         Biological aspects of stem cell sources, differentiation and engineering.  

·         Application of microfluidics to study stem cell dynamics

·         Potential clinical application of stem cells and gene therapy to specific human disease.

·         Utilization of biomaterials and stem cells in regenerative medicine with particular emphasis on spinal cord repair, ligament and bone tissue engineering.

·         Biomimetic multiscale topography for cell alignment.

1. The Mechanism of Stem Cell Differentiation into Smooth

Muscle Cells

Russell Simpson and Qingbo Xu

 2. Recent Advances in Embryonic Stem Cell Engineering Towards Tailored “Lineage Differentiation

Zhen Xu, Jingyu Wang, and Yanan Du

3. Human Amniotic Membrane: A Potential Tissue and Cell Source for Cell Therapy and Regenerative Medicine

Silvia Diaz-Prado, Emma Muiños-Lopez, Isaac Fuentes-Boquete, Francisco J. de Toro, and Francisco J Blanco Garcia

4. Novel Strategies Applied to Provide Multiple Sources of Stem Cells as a Regenerative Therapy for Parkinson’s Disease

Abir O. El Sadik

5. Hair Follicle: A Novel Source of Stem Cells for Cell and Gene Therapy

Panagiotis Mistriotis and Stelios T. Andreadis

 6. Genetically Modified Stem Cells for Transplantation

M. Ian Phillips

7. Induced Pluripotent Stem Cells: Basics, and the Application in Disease Model and Regenerative Medicine

Zhiyong Liu  and Feng Li

8. Gene Transfer to the Heart. Emerging Strategies for the Selection of Vectors, Delivery Techniques and Therapeutic Targets

Michael G Katz, Anthony S Fargnoli, Louella A Pritchette, Charles R Bridges

Carolinas Healthcare System

9. Cell-Based Therapy for Cardiovascular Injury

Yuji Haraguchi, Tatsuya Shimizu, Masayuki Yamato and Teruo Okano

 10. Induced Pluripotent Stem Cells: New Advances in Cardiac Regenerative Medicine

Shinsuke Yuasa, Mitsushige Murata, and  Keiichi Fukuda

11. Dendritic Cells for Cancer Immunotherapy

Nicolas Larmonier  and Emmanuel Katsanis

 12. Mesenchymal stem cells: prospects for cancer therapy

Long-Jun Dai, Xu-Yong Sun, Garth L. Warnock

 13. RNA Interference for Oncology: Clinical Prospects Beyond the Hype

Eishi Ashihara and Taira Maekawa

14. Cell Therapy using Adult Stem Cells in Osteonecrosis and Nonunion Fractures

Jean-Philippe Hauzeur

 15. Stem Cell Therapies for the Treatment of Spinal Cord Injuries: Current Progress in Basic Science and Clinical Research

Hilary North and John Kessler

16. Pluripotent Stem Cells for Neural Regeneration

Syed Ameer Basha Paspala, Aleem Ahmed Khan,

 17. Synovial Mesenchymal Stem Cells and their Applications in Musculoskeletal Regeneration

Yvonne Peck and Dong-An Wang

 18. Stem Cell Therapy Aided liver Regeneration

Ningning Yang and Manrong Jiang

19. Application of Microfluidics of Study Stem Cell Dynamics

Huaying Chen and Robert E. Nordon

 20. Biomimetic Multiscale Topography for Cell Alignment

Kara E. McCloskey

 21. Spinal Cord Repair by Means of Tissue Engineered Scaffolds

Mindan Wang,  Xiongbiao Chen, and  David J. Schreyer

 22. Stem Cells in Ligament Tissue Engineering

Mukai Chimutengwende-Gordon and Wasim Khan

23. Biomaterials for Bone Tissue Engineering

Qizhi Chen

 24. Gene Therapy for the Inner Ear: Progress and Prospects

Hong Sun, Aji Huang, Hong Liu, and Shousong Cao

 25. Preclinical Studies on Growth Plate Cartilage Regeneration Using Chondrocytes or Mesenchymal Stem Cells

Rosa Chung and Cory J Xian

26. Cell and Gene Transfer Strategies for Vascularization During Skin Wound Healing

Benoit Hendrickx, Margot Den Hondt, Kristoff Verdonck, Jan J. Vranckx, and Aernout Luttun