Drug Resistance in Cancer: Mechanisms and Strategies

This book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates.  In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options.

1. Introduction to Drug Resistance in Cancer.- 2. Mechanisms of Cancer Resistance to Various Therapies.- 3. Role of cancer Stem Cells in Drug Resistance.- 4. Immune cells - Critical players in Drug Resistance.- 5. Tumor Microenvironment: Multiway Role in Drug Resistance.- 6. Cancer Drug Resistance and Metabolic Reprogramming.- 7. Epigenetic alterations as an adaptive response to chemotherapy.- 8. Autophagy plays a dual role in drug resistance.- 9. Intracellular compartments and drug resistance.- 10. Gut microbes: Role in cancer and cancer drug resistance.- 11. Novel strategies for overcoming drug resistance.- 12. Future directions and challenges in overcoming drug resistance in cancer.

Dr. Sameer Ullah Khan is currently a Post-Doctoral Fellow at The University of Texas, Genitourinary Medical Oncology- MD Anderson Cancer Center, USA. He has Ph.D. in Cancer Pharmacology (2022) at CSIR- Indian Institute of Integrative Medicine India. His research interest is to decipher the role of cancer stem cells in aggressiveness and therapy resistance with a specialization in cancer metastasis, resistance and drug discovery.  He has been conferred with various prestigious awards notably, the Council of Scientific and Industrial Research- Junior Research Fellowship (JRF) and for Lectureship (LS) /Assistant Professor (CSIR-NET-JRF), CSIR-Senior research fellowship (SRF), The Graduate Aptitude Test in life Science (GATE), The Indian Council of Medical Research (ICMR) and State Eligibility Test (J&K-SET) for Assistant Professor Accredited by U.G.C (2014). He has actively participated in various International and national conferences as well as workshops. He hasserved as a referee for several International journals.  He has more than 8 years of research experience in Cancer pharmacology, Molecular biology, drug discovery, epigenetics and Cell biology. He has also published more than 20 research as well as review articles in peer-reviewed international journals.

Dr. Fayaz Ahmad Malik is a Senior Principal Scientist at CSIR- Indian Institute of Integrative Medicine, Srinagar, India. He has done his Ph.D. in Cancer Biology at Punjab University and a Postdoc at the University of Michigan Ann Arbor, Michigan USA. His research interest is in cancer biology, Chemo-resistance, and cancer drug discovery, and has more than 15 years of research experience. He has been conferred with various prestigious National and International Awards for his contribution to Science. He is serving as a referee and editor for several International journals. Dr. Malik published more than 80 research articles in peer-reviewed international journals and secured several patents. He is a member of many National and international scientific societies and organizations.