Drug Repurposing Innovative Approaches to Drug Discovery and Development

This book offers an insightful exploration of drug repurposing, an innovative approach to drug discovery and development that has the potential to revolutionize the field of medicine. It begins with an introduction to drug repurposing and its history, providing a comprehensive overview of the subject. The readers will embark on a journey through the diverse landscape of drug repurposing strategies. From in silico methods of predicting drug-disease associations to experimental approaches to the integrations of artificial intelligence (AI) and machine learning (ML) in drug repurposing for validating repurposed candidates. The book also delves into the application of drug repurposing in various disease areas, including cancer, inflammatory disorders, and CNS disorders. It explores the potential hurdles involved in the regulatory aspects of the process. The book further covers drug products under clinical trials and provides an overview of the future perspectives of drug repurposing. With its detailed and informative content, this book is a must-read for researchers, clinicians, and healthcare professionals interested in the exciting field of drug repurposing.

Chapter 1. Drug repurposing: History, Significance, Benefits, Approaches and Challenges.- Chapter 2. Methodologies Adopted in Drug Repurposing.- Chapter 3. In silico methods used in drug repurposing.- Chapter 4. Role of artificial and machine learning in drug repurposing.- Chapter 5. Drug repurposing in cancer therapy.- Chapter 6. Drug repurposing in inflammatory disorders.- Chapter 7. Drug repurposing in CNS disorders.- Chapter 8. Reshaping the Therapeutic Landscape: Drug Repurposing for Emerging Infectious Diseases and Rare Diseases.- Chapter 9. Clinical trials on repurposed drugs: an overview.- Chapter 10. Intellectual Property Rights and Regulatory Considerations Throughout Drug Repurposing.- Chapter 11. Redirection to the Drug Discovery: Antidiabetic Drugs Repurposing in Cancer.

Dr. Naveen Chella is an Assistant professor in the Department of Pharmaceutical Technology (Formulations) at the National Institute of Pharmaceutical Education and Research (NIPER) Guwahati under the Ministry of Chemicals and Fertilizers, GoI. His research interests include developing drug delivery systems to improve the physicochemical and biopharmaceutical properties of BCS class II and IV molecules. He also works on developing various delivery systems for the repurposed drugs to enhance their deliverability and therapeutic efficacy. He is a recipient of many awards like “Young Scientists” award from the Telangana Academy of Sciences, best oral and poster awards, travel grant from ICMR and DST and 2 extramural grants from ICMR. He is also Associate Fellow of the Telangana Academy of Sciences. He has a total 13 years of academic and research experience. He has published over 35 peer-reviewed research articles and 7 book chapters. He also serves as a reviewer for more than 20 SCI/SCOPUS-indexed high-impact factor journals. He filed about 7 Indian patents and has 1 granted patent to his credit.

Dr. Om Prakash Ranjan is currently working as an assistant professor at the Department of Pharmaceutical Technology (Formulations), National Institute of Pharmaceutical Education and Research (NIPER), Guwahati. He obtained his Ph.D. in Pharmaceutical Sciences from Manipal College of Pharmaceutical Sciences, Manipal University (now known as MAHE), Karnataka, India. He has a total of 13 years of experience including teaching, research, and industry. He has worked for 7 years in the pharmaceutical industry in the Formulation Research and Development Departments. He is the recipient of an international travel grant from DST and ICMR, Govt of India. His major focus is on the development of controlled and modified-release drug delivery systems, vesicular drug delivery systems based on the Quality by Design (QbD) approach, and solubility enhancement techniques for poorly soluble drugs. To date, he has authored over 20 research articles in various journals of international repute, 7 book chapters, and 2 patents.

Dr. Amit Alexander is presently working as an Associate Professor in the Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER-Guwahati), under the aegis of the Department of Pharmaceuticals (DoP), Ministry of Chemicals and Fertilizers, Government of India (GoI). Dr. Alexander has teaching and research experience of more than 12 years. He is Elected member of the Royal Society of Chemistry (MRSC), London, United Kingdom (UK), Royal Society of Biology (MRSB), London, United Kingdom (UK), Controlled Release Society-Indian Local Chapter (CRS-IC), Mumbai, Indian Academy of Neuroscience (IAN) and a life fellow of Indian Chemical Society (FICS), Kolkata. He has more than 175 scientific publications in high impact factor, SCI indexed, peer review journals to his credit. Dr. Alexander has received many National and International Awards the Young Scientist Award-2013, Young Researcher Award 2020, UGC-JRF National Fellowship 2011, and secured Best research presentation position in many National seminal/conferences. He is recognized as one of the Top 2% Scientific Ranking Worldwide by Stanford University for three consequent years (2020, 2021 and 2022).