Drug Development for Cancer and Diabetes A Path to 2030

Key features include:Details the role of plants for the treatment and management of cancer and diabetesDiscusses the role of phytocompounds as ligands for cancer and diabetic targetsReviews plants and the potential of phytochemicals as antidiabetic and anticancer drugsExplores the green biosynthesis of nanoparticles and their treatment efficiency

PART I CANCER AND LEADS FOR CANCER TREATMENT1. Biomarkers for Screening of Premalignant Lesions and Therapeutic SurveillanceChukwuebuka Egbuna2. Kinase Targets in Cancer Drug DiscoveryS. Usha3. Essential Drug Properties and Stages in Anti-Cancer Drug DevelopmentAndrew G. Mtewa, Duncan Sesaazi, Amanjotannu, and Serawit Deyno4. Plant Constituent as Anti-Cancer DrugsT. Veni, T. Pushpanathan, and G. Vimala5. Anticancer Properties of Some Effective PhytochemicalsMurat Alan and Behnaz Aslanipour6. Therapeutic Aspects of Some Extracts and Purified Cardiac Glycosides Obtained From Nerium oleander LBehnaz Aslanipour and Murat Alan7. Challenging Compounds of Some Medicinal Plants Against CancerN. Shaista Jabeen, L. Jagapriya, B. Senthilkumar, and K. Devi8. Medicinal Plants as Therapeutic Agents in the Treatment of CancerJaya Vikaskurhekar9. Cytotoxic, Apoptosis Inducing Effects and Anti-Cancerous Drug Candidature of JasmonatesParth Thakor, Ramalingam B. Subramanian, Sampark S. Thakkar, and Vasudev R. Thakkar10. Apoptosis Activity of 1,2,-Benzene Dicarboxylic Acid Isolated from Andrographis paniculata on KB, SiHa and IMR Cancer Cell LineP. Krishnamoorthy and D. Kalaiselvan11. Anticancer Drug Discovery From the Indian Spice BoxM. V. N. L. Chaitanya, Santhivardhan Chinni, P. Ramalingam, and Y. Padmanabha Reddy12. Phytochemical Investigation and Evaluation of Anti-Breast Cancer Activity of Chloroform Extract of Tagetes erectaR. Arul Priya, K. Saravanan, and Chukwaebuka Egbuna13. Isolation, Identification and In Silico Evaluation of Anticancer Activity of Flavone from Pisum sativumR. Arul Priya, K. Saravanan, and P. Karuppannan14. Functional Lead Phytochemicals from the Rutaceae and Zingeiberaceae Plants for Development of Anticancer DrugsK. Saravanan, B. Umarani, V. Balan, P. Premalatha, and Bir Bahadur15. In Vitro Anticancer Activity of Biophytum sensitivum on Liver Cancer Lines (HEPG2)M. P. Santhi, K. Saravanan, and P. Karuppannan16. Saffron and Its Active Ingredients: A Natural Product with Potent Anticancer PropertyAshutosh Gupta and Abhay K. PandeyPART I: ANTIDIABETIC DRUG DISCOVERY17. Effects of Pterocarpus marsupium in the Management of Type 2 Diabetes MellitusPriscilla Suresh18. Antidiabetic and Antihyperlipidemic Activities of Cyathea nilgiriensis (Holttum) on STZ Induced Diabetic RatsS. Elavarasi, G. Revathi, K. Saravanan, and Horne Iona Averal19. Antidiabetic Activity of Drug Loaded Chitosan NanoparticleG. Revathi, S. Elavarasi, and K. Saravanan20. Antidiabetic Activity of Silver Nanoparticles Biosynthesized Using Ventilago maderaspatana Leaf ExtractP. Karuppannan, K. Saravanan, and Horne Iona Averal21. Hypoglycemic Activity of Biophytum sensitivum Whole Plant Extracts on Alloxan Induced Diabetic RatsC. Renuka, K. Saravanan, and P. Karuppannan22. Antidiabetic Activity of Ventilago maderaspatana Leaf Extracts on STZ Induced Diabetic RatsP. Karuppannan, K. Saravanan, and P. Premalatha23. Isolation, Identification, and Molecular Docking of Antidiabetic Compounds of Cyatheia nilgiriensis (Holttum)S. Elavarasi, G. Revathi, and K. Saravanan24. Antidiabetic Potentials of Major Indian Spices: A ReviewPratibha, Hema Lohani, S. Zafar Haider, and Nirpendra K. Chauhan25. Aloe Species: Chemical Composition and Therapeutic Uses in Diabetic TreatmentAmit Kumar Singh, Ramesh Kumar, B. Umarani, and Abhay K. Pandey

K. Saravanan, PhD, is Associate Dean of Academic Affairs and Assistant Professor of Zoology, Nehru Memorial College, an affiliated institution of Bharathidasan University, Tamilnadu, India. He has been engaged in teaching, research, and writing for over 15 years.Chukwuebuka Egbuna is a chartered chemist, a chemical analyst, and an academic researcher. He has had many roles at New Divine Favor Pharmaceutical Industry Limited, Nigeria, and Chukwuemeka Odumegwu Ojukwu University, Nigeria. He has published research articles on phytochemistry as well as the 3-volume book Phytochemistry with AAP.Horne Iona Averal, PhD, is Associate Professor at Holy Cross College, Trichy, India. She has received many awards and honors and has been engaged with many academic roles at several colleges and universities. Dr. Averal has published four nucleotide sequences in the NCBI-GENBANK.S. Kannan, PhD, is a specialist in cancer biology and nanomedicine. He has held many roles at national and international academic and scientific bodies and has published a large number of research articles and books in his field.S. Elavarasi, PhD, is Assistant Professor at Holy Cross College, an affiliated institution of Bharathidasan University, Tamilnadu, India. She has been engaged in teaching and research for more than eight years. She has published research articles, book chapters, and books.Bir Bahadur, PhD, was formerly Professor, Chairman, and Head of the Department, as well as Dean of the Faculty of Science at Kakatiya University in Warangal, India. A prolific writer and editor, he received many awards and honors during his long career, including being named as an Eminent Botanist of India.