Drug Addiction I Morphine, Sedative/Hypnotic and Alcohol Dependence

This volume addresses the general problem of drug addiction from several points of view, which are in some ways quite unique and different from other areas of pharmacology. Drug addiction is closely associated with criminal behavior. One of the great and noble edifices of civilization is the philosophic and ethical view that man is perfectible, and some believe that this can be achieved by providing the appropriate circumstance or environment in which man can mature and be educated. Some have postulated that drug abuse is a consequence of an inadequate or pathologic set of socializing experiences or is a consequence of basic conflicts between the values and accepted patterns of behavior of a subculture and that of a larger culture. The degree to which man is malleable and perfectible by social forces is not known nor do we know the true desirability of socializing individuals to the extent that their behavior does not deviate from social norms. Some deviancy is essential for innovation and creativity, and at times there may be difficulties in determining whether an innovator or creator is exhibiting sociopathic behavior or not. This aspect of drug addiction is inherently a matter of social values and ethics.

Section I Problems of Drug Dependence.- 1 General Problems of Drug Abuse and Drug Dependence.- Section II Morphine Dependence.- 1 Neuropharmacology and Neurochemistry of Subjective Effects, Analgesia, Tolerance, and Dependence Produced by Narcotic Analgesics.- 2 Assessment of the Abuse Potential of Narcotic Analgesics in Animals.- 3 Assessment of the Abuse Potentiality of Morphinelike Drugs (Methods Used in Man).- 4 Psychiatric Treatment of Narcotic Addiction.- 5 Chemotherapy of Narcotic Addiction.- 6 Detection of Drugs of Abuse in Biological Fluids.- Section III Sedative/Hypnotics and Alcohol Dependence.- 1 The Pharmacology of Sedative/Hypnotics, Alcohol, and Anesthetics: Sites and Mechanisms of Action.- 2 The Assessment of the Abuse Potentiality of Sedative/Hypnotics (Depressants). (Methods Used in Animals and Man).- 3 Clinical Aspects of Alcohol Dependence.- 4 Abuse of Non-Narcotic Analgesics.- Author Index.