Dopamine and Glutamate in Psychiatric Disorders

An illuminating summary of our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and the therapeutic strategies and possibilities for future treatment. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, and on the origin and progression of Parkinson's disease. Additional chapters offer novel insights into a variety of psychiatric diseases, including ADHD, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques.

Part I. Dopamine Dopamine Receptors Kim A. Neve Dopamine Receptor Alternative Splicing Neil M. Richtand, Laurel M. Pritchard, and Lique M. Coolen Part II. Glutamate Glutamatergic Pathways: Their Relevance for Psychiatric Diseases Yoland Smith Glutamate Receptors: Ionotropic Daniel T. Monaghan, Julia C. A. More, Bihua Feng, and David E. Jane Metabotropic Glutamate Receptors Krystyna Ossowska Part III. Schizophrenia Dopamine and Schizophrenia Bart A. Ellenbroek Glutamate and Schizophrenia and the N-Methyl-d-Aspartate Receptor Hypofunction Hypothesis Stefan Bleich and Johannes Kornhuber Role of Glycine in Schizophrenia Beate D. Kretschmer Part IV. Depression Dopamine and Depression Phil Skolnick Glutamate and Depression Joaquín Del Río and Diana Frechilla Part V. Stress and Aggression Dopamine, Glutamate, and Aggression Klaus A. Miczek and Eric W. Fish Part VI. Anxiety Glutamatergic Systems and Anxiety David N. Stephens Part VII. Attention Deficit Hyperactivity Disorder Dopamine and Glutamate in Attention Deficit Hyperactivity Disorder James M. Swanson, Nora D. Volkow, Jeffrey Newcorn, B. J. Casey, Robert Moyzis, David K. Grandy, and Michael I. Posner Part VIII. Addiction Dopamine-Glutamate Interactions in Reward-Related Incentive Learning Richard J. Beninger and Todor V. Gerdjikov Sensitization and Relapse: Dopamine-Glutamate Interactions David A. Baker and Peter W. Kalivas Glutamatergic Neurotransmission in Sensitization Thomas M. Tzschentke Glutamatergic Mechanisms of Drug Relapse: Withdrawal and Conditioning Factors Anton Y. Bespalov and Robert L. Balster Part IX. Neurodegeneration Dopamine andNeurodegeneration Gabriele Gille and Peter Riederer Glutamate and Neurodegeneration Antonello Novelli, Marcos Pérez-Basterrechea, and Maria Teresa Fernández-Sánchez Part X. Parkinson's Disease Presymptomatic and Symptomatic Stages of Intracerebral Inclusion Body Pathology in Idiopathic Parkinson's Disease Heiko Braak and Kelly Del Tredici Dopamine and Glutamate in Parkinson's Disease: Biochemistry, Clinical Aspects, and Treatment Heinz Reichmann, Bernd Janetzky, and Peter Riederer Dopamine and Glutamate in Motor and Cognitive Symptoms of Parkinson's Disease Werner J. Schmidt Part XI. Huntington's Disease Dopamine and Glutamate in Huntington's Disease Carlos Cepeda, Marjorie A. Ariano, and Michael S. Levine Part XII. Dementias Dopaminergic and Glutamatergic Systems in Alzheimer's Disease Paul T. Francis Index