DNA Repair and Replication Mechanisms and Clinical Significance

DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes, causes of damage, and methods of repair

Preface Editors Contributors 1. Introduction John J. Reynolds, Roger J. A. Grand, and Martin R. Higgs 2. DNA Replication and Cell Cycle Control Sara Priego Moreno, Rebecca M. Jones, and Agnieszka Gambus 3. DNA Replication Termination and Genomic Instability Rebecca M. Jones, Sara Priego Moreno, and Agnieszka Gambus 4. Mechanisms of DNA Damage Tolerance Cyrus Vaziri and Anastasia Zlatanou 5. The Repair of DNA Single-Strand Breaks and DNA Adducts: Mechanisms and Links to Human Disease Alicja Winczura and John J. Reynolds 6. Homologous Recombination at Replication Forks Eva Petermann 7. Mechanism of Double-Strand Break Repair by Non-Homologous End Joining Michal Malewicz 8. Protein Methylation and the DNA Damage Response Martin R. Higgs and Clare Davies 9. Ubiquitin, SUMO and the DNA Double-Strand Break Response Ruth M. Densham, Alexander J. Garvin, and Joanna R. Morris 10. Transcription in the Context of Genome Stability Maintenance Marco Saponaro 11. RNA Binding Proteins and the DNA Damage Response Roger J. A. Grand 12. DNA Replication and Inherited Human Disease John J. Reynolds and Grant S. Stewart 13. Ataxia Telangiectasia and Ataxia Telangiectasia–Like Disorders A. Malcolm R. Taylor 14. DNA Repair Mechanisms in Stem Cells and Implications during Ageing Rachel Bayley and Paloma Garcia 15. Targeting Replication Stress in Sporadic Tumours Marwan Kwok and Tatjana Stankovic 16. A Few of the Many Outstanding Questions John J. Reynolds and Roger J. A. Grand Index

Dr Roger J. A. Grand was an undergraduate in biochemistry at the University of Sheffield, followed by a PhD at the University of Leeds. After a fellowship at Royal Holloway College, University of London, he moved to the Department of Biochemistry at the University of Birmingham to study proteins involved in the regulation of striated muscle contraction. This research helped to define how signals were transmitted through the troponin complex to initiate muscle contraction. After a few years, Roger joined the Department of Cancer Sciences, which later became the Institute for Cancer and Genomic Sciences, at the University of Birmingham. Roger Grand, is now a Reader in Experimental Cancer Sciences, and leads a research group specialising in the study of various aspects of the DNA damage response, both in normal cells and in those undergoing viral infection. Most recently, his lab has been interested in rare inherited diseases linked to mutations in DNA repair proteins. Dr John J. Reynolds earned a degree in genetics and microbiology at the University of Sheffield followed by doctoral research at the Genome Damage and Stability Centre (University of Sussex), where he worked on characterising the molecular defects underlying rare human diseases caused by mutations in DNA single-strand break repair factors. His post-doctoral research at the Cancer and Genomic Sciences (University of Birmingham) has focused on identifying and characterising novel DNA damage response genes, and investigating how defects in DNA repair and DNA replication factors give rise to human diseases, such as microcephalic dwarfism.