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vermorken jan b. (curatore); budach volker (curatore); leemans c. rené (curatore); machiels jean-pascal (curatore); nicolai piero (curatore); o'sullivan brian (curatore) - critical issues in head and neck oncology

Critical Issues in Head and Neck Oncology Key Concepts from the Eighth THNO Meeting

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Dettagli

Genere:Libro
Lingua: Inglese
Editore:

Springer

Pubblicazione: 03/2023
Edizione: 1st ed. 2023





Trama

This is an open access book.

With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up.

All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.




Sommario

The gut microbiota and anticancer immunotherapy, Laurence Zitvogel.- The bidirectional communication between tumor cells and other components of the tumor microenvironment, Phil Sloan.- Resistance mechanisms in immune checkpoint inhibitors and radiotherapy and how to overcome this, Kirsten Lauber.- DNA repair mechanisms as a new target in head and neck cancer, Kevin Harrington.- How to standardize molecular profiling programs for routine patient care, Ingeborg Tinhofer.- Novel immune oncology targets beyond PD-1/PD-L1 in head and neck cancer, Christophe Le Tourneau.- Analytic methods to understand head and neck cancer evolution to guide therapeutic approaches, Ben O’Leary.- Clinical cases, Jean Pascal Machiels.- Updates from the European Head & Neck Society (EHNS), Wojciech Golusinski (President of EHNS)
Section 2:  Primary disease Piero Nicolai.- Sensitivity and specificity of extranodal extension in SCCHN: unlocking the strongest prognostic factor in head and neck cancer, Brian O’Sullivan.- From photon to proton: what’s in it for head and neck cancer patients?, Volker Budach.- Lessons learned from RTOG 1016 and DE-ESCALaTE: what’s next?, Hisham Mehanna.-Treatment intensification in LA-SCCHN: what are the options and for who?, Jan Vermorken.- Immune checkpoint inhibitors in the curative setting: preclinical and clinical data, Jean-Pascal Machiels.- Carcinoma of unknown primary: diagnostics and the potential of transoral surgery, René Leemans.- Clinical cases, Volker Budach.- Individualized therapy in 1-line R/M-SCCHN: what selection criteria should we use?, Petr Szturz.- Patterns of response to immune oncology drugs: how relevant are they in SCCHN?, Amanda Psyrri.- The role of radiotherapy in oligometastatic or oligoprogressive disease in R/M-SCCHN, Daan Nevens.- Updates from the EORTC Head and Neck Cancer Group (HNCG), Jean-Pascal Machiels (Chair of EORTC-HNCG).- Real world evidence in head and neck cancer, Anil D’Cruz (UICC president.- Pathology driven treatment of skull base tumors, Piero Nicolai.- Modern day reconstruction of facial bones, Sat Parmar.- Targeting molecular/minimal residual disease using novel technologies and clinical trials design, Lillian Siu.- New developments in surgery for malignant salivary gland tumors, Jeroen Meulemans.- New systemic therapies in salivary gland cancer, Ethan Argiris. Exercise and nutrition interventions in head and neck cancer, Paolo Bossi.- Telehealth intervention in head and neck cancer patients: a promise?, Irma Verdonck-de Leeuw.




Autore

Prof. Jan B. Vermorken, MD, PhD, started his medical training in 1961, graduated in 1970 from the University of Amsterdam, the Netherlands, and became a board-certified specialist in internal medicine in 1975. Since that time he has worked in the field of Medical Oncology and was officially registered as a Medical Oncologist in the Netherlands in 1992. He received his PhD in Medical Sciences in 1986 from the Vrije Universiteit in Amsterdam. From May 1997 until October 1, 2009, he was appointed Professor of Oncology at the University of Antwerp (UA), in Antwerp, Belgium and head of the Department of Medical Oncology at the University Hospital Antwerp (UZA), in Edegem, Belgium. After his retirement he remained connected to both University (Emeritus Professor) and University Hospital (consultant). His main fields of interest are head and neck oncology and gynecologic oncology. He chaired both the Head and Neck Cancer Group (2006-2009) and the Gynecologic Cancer Group (1983-1989) of the European Organization for the Research and Treatment of Cancer (EORTC). He was founding chair of the Gynecologic Cancer InterGroup (GCIG: 1997-2003) and strongly involved in establishing the Head and Neck Cancer International Group (HNCIG) in 2015.

Professor Vermorken is member of various scientific societies, member of several editorial boards of International journals, reviewer of multiple cancer journals and author or co-author of more than 700 publications. He was Editor-in-Chief of Annals of Oncology from 2009 to 2014 and is chief editor of the head and neck cancer section of The Oncologist (since 2003), and the head and neck section of Frontiers in Oncology (since 2015), is editorial chair of ONCOhemato (multidisciplinary journal; since 2007) in Belgium and chaired Oncotherapie (an internet platform) in The Netherlands (2007-2020). He received the ESMO award in 2007 and on March 1, 2013 he received the title of Commander in the Order of Leopold for his contributions to oncology.

Prof. Volker Budach, MD, is Head of the Departments of Radiation Oncology at the Charité University Medicine Berlin. He became a board-certified radiologist in 1985 and radiation oncologist in 1988 at the University of Essen and was appointed as full professor and chair of the Department for Radiation Oncology at the Charité University Clinics, Campus-Mitte in 1993. He was the founder and the head of the Tumor center Berlin (1994-2011). He was a board member and treasurer of the European Society for Radiotherapy and Oncology (ESTRO) from 1996 till 2004 and chairman of the EORTC Radiation Oncology Group (ROG) from 2000 till 2003, followed by an “executive board” membership of the EORTC and chairman of the "Clinical Research Division" of the EORTC (2003-2006). He was a board member and president of the German Society for Radiation Oncology (DEGRO) from 2005 till 2011. He was a founding member and chair of the German Cooperative Interdisciplinary soft tissue sarcoma group (IAWS)(2006-2012) and a founding and board member of the German Interdisciplinary Head and Neck Group (2008-2019) of the German Cancer Society (DKG). He was additionally appointed as chair of the Department for Radiation Oncology at the Charité-University Medicine Berlin, Campus-Virchow in 2006, and also appointed as chair of the department of Radiation Oncology at the Campus Benjamin-Franklin in 2014. He was a member of the German interdisciplinary Guideline Commissions on Diagnosis, Treatment and Follow-up for breast cancer (2015 until now) and anal cancer (2019-2020). He is a member of many international oncologic societies (e.g. ASCO, ASTRO, ESTRO) and Principle Investigator of several studies in head and neck cancer. He received in 2022 the ESTRO Lifetime Achievement Award and the DEGRO Medal as a founding member of the German Society for Radiation Oncology. He was an author or co-author in 396 publications (PubMed, 10/22).

Professor C. René Leemans, MD, PhD is chair of the Department of Otolaryngology Head and Neck Surgery at the Amsterdam University Medical Centres, VUmc, Amsterdam. He is Director of the Advanced Fellowship Program in Head and Neck Surgery and Oncology at the VU University Medical Centre Amsterdam. His special interests include head and neck oncology, reconstructive and microvascular surgery, and basic research. René Leemans has made a sustained and internationally recognized contribution to cancer care and research in the field of head and neck oncology over the past decades. His scientific standing has been recognized by election as President of the Netherlands Society of Otolaryngology-Head and Neck Surgery, and the Dutch and European Head and Neck Societies. He also serves on the Leadership of the American Head and Neck Society (AHNS). He (co-)authored more than 400 papers and book chapters on head and neck oncology and is regularly invited to speak at international conferences and tutor at courses. He leads the successful Make











Altre Informazioni

ISBN:

9783031231742

Condizione: Nuovo
Dimensioni: 235 x 155 mm Ø 796 gr
Formato: Copertina rigida
Illustration Notes:IX, 365 p. 65 illus., 58 illus. in color.
Pagine Arabe: 365
Pagine Romane: ix


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