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Computational Biology A Statistical Mechanics Perspective




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Dettagli

Genere:Libro
Lingua: Inglese
Pubblicazione: 05/2006
Edizione: 1° edizione





Trama

Devoted to the interface between statistical physics and bioinformatics, Computational Biology: A Statistical Mechanics Perspective focuses on how knowledge of physical properties of biological systems can be used to derive biologically relevant information. The book offers a concise introduction to physical mechanisms underlying biological functions on molecular and system levels. It integrates knowledge and tools from statistical physics and computer science to provide mathematical tools for meeting challenges in computational biology. With summaries of biological information, this is ideal for students, researchers, and practitioners in bioinformatics and computational biology.




Note Editore

Quantitative methods have a particular knack for improving any field they touch. For biology, computational techniques have led to enormous strides in our understanding of biological systems, but there is still vast territory to cover. Statistical physics especially holds great potential for elucidating the structural-functional relationships in biomolecules, as well as their static and dynamic properties.Breaking New GroundComputational Biology: A Statistical Mechanics Perspective is the first book dedicated to the interface between statistical physics and bioinformatics. Introducing both equilibrium and nonequilibrium statistical mechanics in a manner tailored to computational biologists, the author applies these methods to understand and model the properties of various biomolecules and biological networks at the systems level. Unique Vision, Novel ApproachBlossey combines his enthusiasm for uniting the fields of physics and computational biology with his considerable experience, knowledge, and gift for teaching. He uses numerous examples and tasks to illustrate and test understanding of the concepts, and he supplies a detailed keyword list for easy navigation and comprehension. His approach takes full advantage of the latest tools in statistical physics and computer science to build a strong set of tools for confronting new challenges in computational biology.Making the concepts crystal clear without sacrificing mathematical rigor, Computational Biology: A Statistical Mechanics Perspective is the perfect tool to broaden your skills in computational biology.




Sommario

STATISTICAL MECHANICSEquilibrium Statistical MechanicsZ: The Partition FunctionRelation to ThermodynamicsComputing ZNonequilibrium Statistical MechanicsStochastic ProcessesThe Master EquationFluctuation TheoremsThe Fokker-Planck and Langevin EquationsSequence Alignment: A Nonequilibrium Phase TransitionBIOMOLECULESMolecules, Code and RepresentationDNA and RNA: The Building BlocksRepresenting RNA StructureProteinsDNAThermal Stability of DNA: The Melting TransitionThe Melting Profiles of Genomic DNA and cDNAHybridizing DNARNAComputing RNA Secondary Structure: CombinatoricsThe RNA Partition FunctionRNA Phase Behavior and Folding KineticsProteinsProteins: FoldingProteins: DockingElectrostaticsChromatinBacterial Chemotaxis: Cooperativity Once MoreNETWORKSNetwork Dynamics I: DeterministicDeterministic Dynamics: ?-Repressor ExpressionThe Turing InsightThe Min SystemNetwork Dynamics II: FluctuationsNoise in SignalingStochastic CascadesStochastic FocusingFluctuating Gene Network DynamicsExtrinsic vs. Intrinsic NoiseNetworks: StructureNetworks as GraphsProbability Generating Functions and Network CharacteristicsStatistical Mechanics of NetworksNetwork GrowthINDEX










Altre Informazioni

ISBN:

9781584885566

Condizione: Nuovo
Collana: Chapman & Hall/CRC Mathematical and Computational Biology
Dimensioni: 9.25 x 6.125 in Ø 1.15 lb
Formato: Copertina rigida
Illustration Notes:60 b/w images, 8 color images, 4 tables and 500 equations
Pagine Arabe: 276


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