CNS Injuries Cellular Responses and Pharmacological Strategies

Featuring up-to-date reviews of the most important areas of study regarding cellular and molecular responses of the brain to injury, this book introduces the problem of CNS damage at the cellular, immune, and vascular levels. CNS Injuries: Cellular Responses and Pharmacological Strategies discusses possible therapeutic strategies for manipulating major events in the injury response, including: inflammatory and immune reactions; scarring; neuron death; demylenation and remyelination; axonal regeneration; reestablishment of neuronal connectivity. This enlightening reference is sure to benefit researchers and practitioners in a broad range of disciplines, including pharmacology, pathology, toxicology and many others. TOC:Cellular Responses to Penetrating CNS Injury. - Cellular Responses to Ischaemic CNS Injury. - The Immune Response and CNS Injury. - Haematogenous Cell Responses to CNS Injury. Role of Macrophages and Microglia in the Injured CNS. - Cellular Trafficking. Protease Inhibitors and Microglia/Macrophage-Modulating Drugs Prevent Microglia-Mediated Neuronal Death in the Traumatized and Dystrophic Retina. Transforming Growth Factor-b and CNS Scarring. Neurotrophic Factors. Fibroblast Growth Factors. Index.

The basic science of the cellular and molecular responses of the brain to injury is a rapidly expanding area of research that provides evidence of growing opportunities for pharmacological intervention in the clinic. CNS Injuries: Cellular Responses and Pharmacological Strategies is an up-to-date examination of new developments in our understanding of the cellular and trophic responses to CNS injuries and the potential treatment. This text collates reviews of the most important areas of study regarding injury response including inflammatory and immune reactionsscarringneuron deathdemyelination and remyelinationaxonal regenerationre-establishment of neuronal connectivityProviding a record of recent advances that will help point the way to future developments, this enlightening reference is sure to benefit researchers and practitioners in a broad range of disciplines, including: neurology, pharmacology, pathology, toxicology, immunology, and many others.

Cellular Responses to Penetrating CNS Injury, M. Berry, A. Butt, and A. LoganCellular Responses to Ischaemic CNS Injury, W.L. MaxwellImmune Response and CNS Injury, N.A. GregsonHaematogenous Cell Responses to CNS Injury, K.A. Brown and B.A. KhoshkbijariRole of Macrophages and Microglia in the Injured CNS, W.J. StreitCellular Trafficking, A.J. Vora and K.A. BrownMicroglia-Mediated Prevention of Traumatic Neurodegeneration S. Thanos, R. Naskar, and P. HeiduschkaTransforming Growth Factor-b and CNS Scarring, A. Logan and M. BerryNeurotrophic Factors, T. HaggFibroblast Growth Factors, C. Grothe, C. Meisinger, and K. WewetzerIndexAudienceResearchers and practitioners involved in: pharmacology, pathology, toxicology, neurophysiology, neuroanatomy, molecular biology, and cellular biology; Medical students

Martin Berry