Clinical Tuberculosis

Entirely updated and revised, the 6th edition of Clinical Tuberculosis continues to provide the TB physician with a definitive and erudite account of the latest techniques in diagnosis, treatment and control of TB, including an overview of the latest guidelines from the CDC and WHO. With an increased emphasis on the clinical aspects and treatment, this book will be an invaluable resource to the TB practitioner in public health or clinical practice and an ideal reference to laboratory staff. Key Features Completely updated and reorganized Includes brand new chapters on radiology and an overview of the latest WHO, ATS/CDC/IDSA, ERS, NICE, CTS and IUATLD guidelines Clinically focused to provide up-to-date guidance on diagnosis, treatment and control Edited by three renowned experts in the field of tuberculosis

Foreword Preface Editors Contributors I. BACKGROUND 1. The History of Tuberculosis from Earliest Times to the Development of Drugs Charlotte A. Roberts and Jane E. Buikstra 2. Epidemiology Grant Theron, Ted Cohen, and Christopher Dye II. PATHOLOGY AND IMMUNOLOGY 3. Mycobacterium tuberculosis: The Genetic Organism William R. Jacobs, Jr. 4. Pathogenesis of Tuberculosis Divya B. Reddy and Jerrold J. Ellner III. TRANSMISSION 5. Using Genotyping and Molecular Surveillance to Investigate Tuberculosis Transmission Sarah Talarico, Laura F. Anderson, and Benjamin J. Silk 6. Tuberculosis Transmission Control Edward A. Nardell IV. DIAGNOSIS OF ACTIVE DISEASE AND LATENTINFECTION 7. Diagnosis of Active Pulmonary Tuberculosis J. Lucian Davis 8. Radiology of Mycobacterial Disease Anne McB. Curtis 9. Diagnosis of Latent TB Infection Ajit Lalvani, Clementine Fraser, and Manish Pareek V. DRUGS AND VACCINES FORTUBERCULOSIS 10. Clinical Pharmacology of the Anti-Tuberculosis Drugs Gerry Davies and Charles Peloquin 11. New Developments in Drug Treatment Alexander S. Pym, Camus Nimmo, and James Millard 12. BCG and Other Vaccines Rachel Tanner and Helen McShane VI. CLINICAL ASPECTS AND TREATMENT 13. Pulmonary Tuberculosis Charles S. Dela Cruz, Barbara Seaworth, and Graham Bothamley 14. Extrapulmonary Tuberculosis Charles L. Daley 15. Tuberculosis and Human Immunodeficiency Virus Coinfection Charisse Mandimika and Gerald Friedland 16. Drug-Resistant Tuberculosis Keertan Dheda, Aliasgar Esmail, Anzaan Dippenaar, Robin Warren, Jennifer Furin, and Christoph Lange 17. The Surgical Management of Tuberculosis and Its Complications Richard S. Steyn 18. Tuberculosis in Childhood and Pregnancy Lindsay H. Cameron and Jeffrey R. Starke 19. Treatment of Latent Tuberculosis Infection Including Risk Factors for the Development of Tuberculosis Martin Dedicoat VII. OFFICIAL STATEMENTS: COMPARISON OF NATIONAL AND INTERNATIONAL RECOMMENDATIONS 20. Treatment Guidelines for Active Drug-Susceptible and Drug-Resistant Pulmonary Tuberculosis, and Latent Tuberculosis Infection Lynn E. Sosa and Lloyd N. Friedman VIII. CONTROL 21. Tuberculosis Epidemic Control: A Comprehensive Strategy to Drive Down Tuberculosis Salmaan Keshavjee, Tom Nicholson, Aamir J. Khan, Lucica Ditiu, Paul E. Farmer, and Mercedes C. Becerra IX. RELATED ASPECTS 22. Animal Tuberculosis Catherine Wilson Index

Lloyd N. Friedman, M.D., is a Clinical Professor of Pulmonary, Critical Care and Sleep Medicine at the Yale School of Medicine, New Haven, CT. He is Director of Inpatient Quality and Safety for the Department of Internal Medicine. He is a member of the American Thoracic Society, a member of the Society of Critical Care Medicine, a fellow of the American College of Chest Physicians and a member of the International Union Against Tuberculosis and Lung Disease. He is Chairman of the Connecticut Tuberculosis Elimination Advisory Committee. Martin Dedicoat PhD, FRCP, BSc, DTM&H is a Consultant physician in infectious diseases at the University Hospitals Birmingham. He is currently clinical lead for tuberculosis for Birmingham and Solihull, UK. His main research interests center around tuberculosis transmission in urban settings. Dr Dedicoat is a member of the British Thoracic Society drug resistant tuberculosis management group advising on management of complex tuberculosis patients across the UK. He also sits on the National Tuberculosis board for England. Dr. Peter D. O. Davies graduated in 1966 from Marlborough College, Wilts, UK and obtained his BM, BCh and MA from University College, Oxford, UK in 1971 and St. Thomas’s Hospital in London in 1973. He gained a DM from oxford in 1984. He was a Consultant General and Respiratory Physician at Aintree University Hospital from 1988 to 2011 and at Liverpool Heart Chest Hospital from 1988 to 2015. He is or has been a member of the British Medical Association, the British Thoracic Society, the European Respiratory Society, the Royal College of Physicians of London (Fellow), the Royal Society of Medicine, the American Thoracic Society, the North Western Society of Respiratory Physicians where he served as President in 2007, the International Union Against Tuberculosis and Lung Disease where he was Chair of the Tuberculosis Section, President of the European section, and Editor in Chief of the International Journal of Tuberculosis and Lung Disease, and a member of NICE where he was chair of the Tuberculosis Section. He co-founded the UK Based TB charity in 1998. Dr. Davies is an expert in tuberculosis and edited the inaugural edition of the textbook, Clinical Tuberculosis in 1994 and has continued as editor for the subsequent 5 editions.