Chronic Lymphocytic Leukemia Molecular Genetics, Biology, Diagnosis, and Management

A comprehensive and critical review of the latest scientific advances in our understanding of the molecular genetics and biology of CLL and their application to the best management of CLL. The authors focus on diagnosis, prognosis, multifaceted treatment options, and complications. Among the diverse treatments considered are chemotherapy, autologous and allogenic transplantations, monoclonal antibody therapy, immunotoxin therapy, gene therapy, and several new therapeutic strategies. Familial and juvenile chronic lymphocytic leukemia are also discussed.

Part I. Introduction The Natural History of CLL: Historical Perspective Gerald E. Marti and Vincent Zenger Part II. Biology and Genetics Genetics of B-Cell Chronic Lymphocytic Leukemia Stephan Stilgenbauer, Peter Lichter, and Hartmut Döhner Molecular Biology of Chronic Lymphocytic Leukemia William G. Wierda The Heterogeneous Origin of the B-CLL Cell Terry Hamblin Pathogenesis of Impaired Cellular Immune Function in CLL Patrick B. Johnston and Neil E. Kay Cytokines and Soluble Molecules in CLL Enrica Orsini and Robin Foa Part III. Clinical Aspects: Diagnosis Immunophenotypic Differential Diagnosis and Cell Cycle Analysis Vonda K. Douglas and Raul C. Braylan Common Cytogenetic Abnormalities Gunnar Juliusson Immunophenotypic Diagnosis of Leukemic B-Cell Chronic Lymphoproliferative Disorders Other Than Chronic Lymphocytic Leukemia Alberto Orfao, Julia Almeida, Maria Luz Sanchez, and Jesus F. San Miguel Part IV. Clinical Aspects: Prognosis Staging of Chronic Lymphocytic Leukemia, Kanti R. Rai and Niraj Gupta. Prognostic Indicators of Chronic Lymphocytic Leukemia, Francesc Bosch and Emili Montserrat Part V. Clinical Aspects: Treatment Guidelines for Clinical Management of CLL Guillaume Dighiero Chemotherapy of Chronic Lymphocytic Leukemia Alessandra Ferrajoli, Michael J. Keating, and Susan M. O'Brien Autologous and Allogeneic Transplantations for Chronic Lymphocytic Leukemia Mauricette Michallet Monoclonal Antibody Therapy in Chronic Lymphocytic Leukemia Thomas S. Lin, Margaret S. Lucas, and John C. Byrd Immunotoxin Therapy of Chronic Lymphocytic Leukemia Arthur E. Frankel and Robert J. Kreitman New Treatment Strategies in Chronic Lymphocytic Leukemia Upendra P. Hegde and WyndhamH. Wilson Gene Therapy of Chronic Lymphocytic Leukemia Januario E. Castro and Thomas J. Kipps Part VI. Clinical Aspects: Complications Infections in Patients With Chronic Lymphocytic Leukemia Gerald P. Bodey, Dimitrios Kontoyiannis, and Michael J. Keating Autoimmune and Hypersplenic Cytopenias Terry Hamblin Clonal Evolution and Second Malignancies in B-CLL Guy B. Faguet Part VII. Familial and Juvenile Chronic Lymphocytic Leukemia Inherited Predisposition to Chronic Lymphocytic Leukemia Martin R. Yuille, Daniel Catovsky, and Richard S. Houlston Young Patients With Chronic Lymphocytic Leukemia Francesca R. Mauro and Robin Foa Index