Cerebral Ischemic Reperfusion Injuries (CIRI) Bench Research and Clinical Implications

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion.

Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China.

Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine

Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China.

Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University.

John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

Introduction

The summary of Pangu stroke meeting and overview

Lusha Tong, John H. Zhang

Chapter 1

Gelatinase-mediated Impairment of Microvascular Beds in Cerebral Ischemia and Reperfusion Injury

Chapter 2

Characters of ischemic stroke and recanalization arteries

Qingqing Dai, Shujuan Li, Junfa Li

Chapter 3

Cerebral Ischemic Reperfusion Injury (CIRI) Cases

Wei-Jian Jiang, MD, PhD; Yi-Qun Zhang

Chapter 4

Qingmeng Chen, MS, Min Lou, MD, PhD

Programmed cell death in CIRI

Ruili Wei, Yan Xu, Jie Zhang, Benyan Luo

Chapter 6

Abhishek Mishra¹, Rachana Nayak¹, Dandan Sun¹

Chapter 7

Oxidative Stress and Nitric Oxide in Cerebral Ischemic Reperfusion Injury

Chapter 8

Extracellular Matrix in Stroke

Yao Yao

Inflammation and Ischemic Stroke

Junwei Hao, MD, PhD, Kai Zheng, Heng Zhao, PhD

Chapter 10

Cerebral vascular injury in diabetic ischemia and reperfusion

Haibin Dai

Chapter 11

Ischemia/reperfusion damage in diabetic stroke 

Poornima Venkat, PhD, Michael Chopp, PhD, Jieli Chen, MD

Chapter 12

Current understanding of pathology and therapeutic status for CADASIL

Chapter 13

Blood Pressure and Cerebral Ischemic Reperfusion Injury

Wei-Jian Jiang, MD, Ph.D.; Chen Li, MD, Ph.D.; Mohamad Orabi MD, Wuwei Feng

Chapter 14

Collateral circulation and cerebral ischemia reperfusion injury

Qinghai Huang, Wanling Wen

Chapter 15

Controlled Reperfusion against Ischemia Reperfusion Injury

Wei-Jian Jiang, MD, PhD; Jin Lv, PhD; Ying-Ying Zhang, PhD; Kai Wang

Chapter 16

Therapeutic Window beyond Cerebral Ischemic Reperfusion Injury

Wengui Yu, MD, PhD¹ and Liping Liu, MD, PhD