Cancer in Organ Transplant Recipients

In about 5% of all organ (kidney, liver) transplant recipients, malignancies occur as a late complication of the massive immunosuppression. The malignancies are mainly skin cancers, lymphomas and renal carcinomas. The present book discusses the possible mechanisms of this type of tumorigenesis and inquires into possibilities of prevention. In particular, the described malignancies might be of viral origin. The book informs about a completely new type of carcinogenesis. Apart from the scientific aspects, it is of great practical value.

I De Novo Cancer in Organ Transplant Patients.- Animal Models of Cancer Caused by Immunosuppression.- Malignancies in Man After Organ Transplantation.- Malignant Lymphoproliferation of Viral Origin in Transplant Patients.- Clonality of Post-transplant Lymphoproliferative Diseases.- Post-transplant Kidney Cancers and Skin Cancers (Including Kaposi’s Sarcoma).- Discussion.- II Treatment of Cancer by Organ Transplantation.- Liver Transplantation for Malignant Disease.- Bone Marrow Transplantation.- Transplantation of the Upper Gastrointestinal Organs in Malignant Diseases.- Discussion.- III Possible Causes of Cancer in Transplant Patients.- The Nordic Project on Renal Transplantation and Cancer.- Human Papillomaviruses.- Immune Response Directed Against Epstein-Barr Virus Carrier B Lymphocytes.- Carcinogenic Effects of Immunosuppressive Drugs in Man.- Influence of Blood Transfusions and Immunosuppressive Therapy on Malignancies in Renal Transplant Recipients.- Possible Causes of Cancer in Transplant Patients.- Discussion.- IV Possible Prevention of De Novo Cancer in Transplant Patients.- Post-transplant Malignancies: Clinical Preventive Measures.- Immunologic Measures: Unresponsiveness or Tolerance.- New Immunosuppressive Drugs.- Cancer Related to Organ Transplantation: Summary and Conclusions.- Discussion.