Bone marrow stem cell therapy for stroke

This book covers recent advances in all aspects of bone marrow-derived stem cells (BMSCs) for stroke treatment, while also providing comprehensive information on human clinical trials and animal models of stroke. In addition, it reviews the optimal conditions of transplantation for stroke therapy and potential mechanisms underlying transplanted cell-mediated functional recovery after stroke. As the first book to focus on BMSC therapy for stroke, it also discusses in depth the unique challenges of BMSCs-based therapy in this context.

The Preface.- Chapter 1 Ischemic stroke pathophysiology and cell therapy .- Chapter 2 Bone Marrow Stem Cells: Source, Characterization, Isolation, Culture and Identification .- Chapter 3 Mobilization and homing of bone marrow stem cells .- Chapter 4 Interaction of bone marrow stem cells with other cells .- Chapter 5 Mesenchymal stem cells for stroke therapy .- Chapter 6 Bone Marrow Hematopoietic Stem Cell Therapy in Stroke .- Chapter 7 Endothelial progenitor cells therapy in stroke .- Chapter 8 Co-transplantation strategies and combination therapies for stroke .- Chapter 9 Modification of bone marrow stem cells for homing and survival during cerebral ischemia .- Chapter 10 Clinical studies of bone marrow-derived stem cells therapy in stroke patients .- Chapter 11 Bone Marrow Stem Cell delivery methods, routes, time, efficacy and safety .- Chapter 12 Potential Mechanisms of Transplanted Cell-mediated Recovery After Stroke .- Chapter 13 Bone marrow stem cell stimulating factors and brain recovery after stroke .- Chapter 14 Imaging and tracking transplanted bone marrow stem cells after stroke.

Dr. Kunlin Jin is a tenured Professor at the University of North Texas Health Science Center, USA. His primary research interests are in aging and diseases. He has pursued research in several areas related to stroke and has made significant contributions concerning the treatment of brain diseases by cell replacement using stem cells. Dr. Jin has published over 200 research papers in prominent journals including JCI, PNAS, Nature, etc. and has a personal H-index of 56. Furthermore, he is Editor-in-Chief of the journal “Aging and Disease” and co-founder of the International Society on Aging and Disease.

Dr. Qichuan Zhuge is a Professor at the Department of Neurosurgery, Chairman of the Brain Center and Vice president at the first hospital of Wenzhou Medical University, China.

Dr. Xunming Ji is a Professor of Neurosurgery at Capital Medical University and Vice-President of Xuanwu Hospital, China. He was a principal investigator for National Science Fund for Distinguished Young Scholars of China (2013) and was a Cheung Kong Scholar of Ministry of Education of China (2014).