Bioactive-Loaded Nanomedicine for the Management of Health and Disease

The new book focuses on the use of natural active substances and nutraceuticals in nano-research for improved healthcare management and applications. It explores advanced nanomaterials that can be utilized for the encapsulation of nutrients, vitamins, and phytoconstituents for the treatment of cancer, psychotic and manic disorders, and chronic inflammation, such as arthritis and psoriasis, as well as for other healthcare issues, such as skin diseases and skin care, atherosclerosis, and more. The chapters discuss the remarkable advantages of using new bioactive and nutraceutical drugs, which offer improved solubility, bioavailability, simultaneous drug delivery, safety extension, long-term delivery, better dissemination of tissue macrophages, security against toxicity, increase in pharmacological activity, and enhanced physical and chemical protection.

PART 1: Bioactive-Loaded Nanomedicine as Anticancer Potential 1. Phyto-Actives and Their Targeted Action in Management of Hepatocellular Carcinoma: Scope of Nanomedicine in Its Effective Delivery Mahfoozur Rahman, Kainat Alam, Khalid S. Alharbi, Waleed Hassan Almalki, Nabil K. Alruwaili, Sarwar Beg, and Shipra Daniel 2. Thymoquinone-Loaded Nanomedicines for Triple-Negative Breast Cancer Treatment Md. Abul Barkat, Harshita, Anjali Goyal, Md. Sarfaraj Hussain, Sarwar Beg, Mahfoozur Rahman, Khalid S. Alharbi, and Farhan J. Ahmad 3. Nucleic Acid-Loaded Nanomedicines with Enhanced Anticancer Potential Behiye Senel and Büyükköroglu 4. Breast Cancer Therapy by Combinatorial Herbo-Synthetic Nanocarrier Bharti Mangla, Pankaj Kumar, Kamya Goyal, Kanchan Kohli, and Shammy Jindal PART 2: Phytoactives-Loaded Nanocarriers as Antipsychotic and Antimanic Potential 5. Antipsychotics and Antimanics: An Insight into Mechanism of Action of Natural Compounds Partha Pratim Das, S. K. Batin Rahaman, Md. Adil Shaharyar, Mahfoozur Rahman, Kainat Alam, Imran Kazmi, Kumar Anand, Monalisha Sengupta, Sasmita Dash, and Sanmoy Karmakar 6. Plant-Derived Anti-Psychotic Drugs: An Insight into Receptor and Phytoconstituent Interaction Partha Pratim Das, S. K. Batin Rahaman, Md. Adil Shaharyar, Rudranil Bhowmik, Avishek Mandal, and Sanmoy Karmakar 7. Plant Bioactive Compounds andTheir Nanoformulations for the Treatment of Alzheimer’s Disease Dhara Lakdawala and Farhan J. Ahmad PART 3: Phytoactives-Encapsulated Nanocarriers as Anti-Inflammatory Potential 8. Bioactives-Loaded Nanomedicines for Arthritis Treatment Priyanka Prabhu, Galvina Pereira, and Clara Fernandes 9. Curcumin-Loaded Nanocarriers for Anti-Inflammatory Applications Md. Akbar, Kainat Alam, Md. Afroz Alam, Sarwar Beg, Afroze Alam, Mahfoozur Rahman and Shipra Daniel 10. Management of Psoriasis: Delivery Approaches for Synthetic and Herbal Drugs Navdeep Singh, Kamya Goyal, Rajendra Awasthi, Veera Garg, and Shammy Jindal PART 4: Bioactive-Encapsulated Nanocarrier in Other Healthcare Applications 11. Phytochemical-Based Nanocosmoceuticals for Beauty and Skin Therapy Madhu Gupta, Manupriya Chaudhari, Manisha Sharma, and Sandeep Saini 12. Vitamin-Loaded Nanocarriers as Nutraceuticals in Healthcare Applications Madhu Gupta, Radha Aggarwal, Neha Raina, and Azmi Khan 13. Key Roles of Nutrients in Healthcare and Their Drug Delivery Approach Tabish Mehraj 14. Nanotechnology-Based Drug Delivery System Used for Loading of Umbelliferone: A Review Shikha Kesharwani, Dilip Kumar Patel, Roohi Kesharwani, and Vikas Kumar 15. Emergence of Nanophytomedicine in Healthcare Setting Dharmila, Sarwar Beg, Md. Abul Barkat, Mahfoozur Rahman, and Farhan J. Ahmad 16. Therapeutic Benefit of Polygala senega and Senegin in Medicine: A Concise Report of Their Therapeutic Potential Dinesh Kumar Patel, Kanika Patel, Mahfoozur Rahman, Vikas Kumar, and Omji Porwal 17. The Health Benefit of Gossypetin: (A Flavonoid, Against Inflammation and Atherosclerosis): A Systematic Review of Pharmacology and Bioanalytical Tools Kanika Patel and Amita Verma

Mahfoozur Rahman, PhD, is Assistant Professor at the Department of Pharmaceutical Sciences at Sam Higginbottom University of Agriculture, Technology & Sciences, India. His research focuses on development and characterization of nanosized drug delivery systems for inflammatory disorders. To date, he has published over 100 publications in peer-reviewed journals as well as book chapters, books, and articles in international magazines. He is also a guest editor for several journals. Sarwar Beg, PhD, is Assistant Professor at the School of Pharmaceutical Education and Research, Jamia Hamdard (Hamdard University), New Delhi, India. He has nearly a decade of experience in systematic development and characterization of novel and nanostructured drug delivery systems using QbD paradigms, including design of experiments (DoE) and quality risk management (QRM). He has published review/research journal articles, book chapters, books, and journal special issues. Khalid S. Alharbi, PhD, is Assistant Professor in the Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia. His major area of research is cancer, focusing on drug discovery, nanomedicine, and preclinical pharmacological and toxicological studies of anticancer agents. He has published several articles in peer-reviewed journals and has presented papers at numerous international conferences. Waleed Hassan Almalki, PhD, is Professor of Pharmacology at the College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia. His research is focused on host-virus networks in Hepacivirus C disease progression and host-virus genes expression during oxidative stress, hepatic steatosis, fibrosis, and hepatocellular carcinoma. He has published on HCV pathogenesis and treatment and drug designing, as well as angiogenesis, pharmacological assays, and infectious disease epidemiology. Nabil K. Alruwaili, PhD, is Assistant Professor and Chairman of the Pharmaceutics Department at the School of Pharmacy, Jouf University, Saudi Arabia. Previously, he worked at the Saudi Food and Drug Authority (SFDA) in product evaluation and standards-setting administration. He has several published articles and has presented papers at international and national scientific conferences. Majed Al Robaian, PhD, is Dean of the Faculty of Pharmacy at Taif University in Saudi Arabia. He was previously Director of Pharmacy at King Abdulaziz Hospital. He is also a Science Faculty Ambassador for Strathclyde University, UK, and a member of several committees of the Saudi Commission for Health Specialties. His research interests focus on the delivery of therapeutic genes for the treatment of cancer.